DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_COP1_1

Location: 410:420

E3 ligase: COP1

DEGRON score: 0.8597

ASA_SCORE: 96.2

COIL: 0.9723

CONS_SCORE: 0.4889

DSS_SCORE: 0.6034

HELIX: 0.007

FCONS_SCORE: 1.0645

RIG_SCORE: 0.5897

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T405K	TCGA-AR-A256	BRCA	TCGA	TSPTPNPVPSV	DEG_COP1_1	0.1944
p.T405K	DO4155	BRCA	ICGC	TSPTPNPVPSV	DEG_COP1_1	0.1944
p.P416R	TCGA-DU-A5TU	LGG	TCGA	TSPTPNPVPSV	DEG_COP1_1	0.6401
p.P416R	DO44579	LGG	ICGC	TSPTPNPVPSV	DEG_COP1_1	0.6401
p.P416T	TCGA-EB-A553	SKCM	TCGA	TSPTPNPVPSV	DEG_COP1_1	0.5919
p.P416T	DO47329	SKCM	ICGC	TSPTPNPVPSV	DEG_COP1_1	0.5919
p.A429D	DO229031	LICA	ICGC	TSPTPNPVPSV	DEG_COP1_1	0.0833
p.A429D	DO229008	LICA	ICGC	TSPTPNPVPSV	DEG_COP1_1	0.0833
p.S411F	DO229058	LICA	ICGC	TSPTPNPVPSV	DEG_COP1_1	0.7982
p.A406D	DO229006	LICA	ICGC	TSPTPNPVPSV	DEG_COP1_1	0.2222
p.P421S	DO229213	THCA	ICGC	TSPTPNPVPSV	DEG_COP1_1	0.3056
p.P428S	SIDM00217	Colorectal Carcinoma	GDSC	TSPTPNPVPSV	DEG_COP1_1	0.1111
p.P428S	ACH-000999	Colon/Colorectal Cancer	CCLE	TSPTPNPVPSV	DEG_COP1_1	0.1111
p.P428S	SNU-1040	large_intestine	COSMIC	TSPTPNPVPSV	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51610	Host cell factor 1	DEG_COP1_1	410:420	TSPTPNPVPSV	COP1	0.8597	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons