DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_SPOP_SBC_1

Location: 1471:1475

E3 ligase: SPOP

DEGRON score: 0.8409

ASA_SCORE: 84.76

COIL: 0.7658

CONS_SCORE: 0.4731

DSS_SCORE: 0.4604

HELIX: 0.0204

FCONS_SCORE: 0.9989

RIG_SCORE: 0.7433

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1476M	TCGA-2W-A8YY	CESC	TCGA	AITTT	DEG_SPOP_SBC_1	0.3056
p.V1476M	DO223732	CESC	ICGC	AITTT	DEG_SPOP_SBC_1	0.3056
p.R1482L	TCGA-66-2734	LUSC	TCGA	AITTT	DEG_SPOP_SBC_1	0.1389
p.R1482L	TCGA-D3-A2J6	SKCM	TCGA	AITTT	DEG_SPOP_SBC_1	0.1389
p.R1482L	DO26430	LUSC	ICGC	AITTT	DEG_SPOP_SBC_1	0.1389
p.R1482L	DO37901	SKCM	ICGC	AITTT	DEG_SPOP_SBC_1	0.1389
p.R1482W	TCGA-A5-A2K3	UCEC	TCGA	AITTT	DEG_SPOP_SBC_1	0.1389
p.R1482W	DO1131	BRCA	ICGC	AITTT	DEG_SPOP_SBC_1	0.1389
p.R1482W	DO43899	UCEC	ICGC	AITTT	DEG_SPOP_SBC_1	0.1389
p.A1471V	TCGA-AX-A2HD	UCEC	TCGA	AITTT	DEG_SPOP_SBC_1	0.5825
p.A1471V	DO42608	UCEC	ICGC	AITTT	DEG_SPOP_SBC_1	0.5825
p.S1478F	TCGA-EE-A2GL	SKCM	TCGA	AITTT	DEG_SPOP_SBC_1	0.25
p.S1478F	DO37434	SKCM	ICGC	AITTT	DEG_SPOP_SBC_1	0.25
p.T1481M	DO228483	BRCA	ICGC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	SIDM00434	Plasma Cell Myeloma	GDSC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	SIDM00565	Oral Cavity Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	SIDM00580	Acute Myeloid Leukemia	GDSC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	SIDM00988	Kidney Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	SIDM00170	Head and Neck Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	SIDM01446	Glioblastoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	SIDM01442	Glioma	GDSC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	BFTC-909	kidney	COSMIC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	OSC-20	upper_aerodigestive_tract	COSMIC	AITTT	DEG_SPOP_SBC_1	0.1667
p.T1481M	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	AITTT	DEG_SPOP_SBC_1	0.1667
p.N1465K	DO229459	SKCA	ICGC	AITTT	DEG_SPOP_SBC_1	0.1667
p.I1466T	DO229213	THCA	ICGC	AITTT	DEG_SPOP_SBC_1	0.1944
p.T1473M	SIDM00781	Colorectal Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.7423
p.T1473M	SIDM00780	Colorectal Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.7423
p.T1473M	ACH-000967	Colon/Colorectal Cancer	CCLE	AITTT	DEG_SPOP_SBC_1	0.7423
p.T1473M	ACH-001199	Colon/Colorectal Cancer	CCLE	AITTT	DEG_SPOP_SBC_1	0.7423
p.T1473M	SNU-C2B	large_intestine	COSMIC	AITTT	DEG_SPOP_SBC_1	0.7423
p.R1482Q	SIDM00217	Colorectal Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.1389
p.R1482Q	ACH-000999	Colon/Colorectal Cancer	CCLE	AITTT	DEG_SPOP_SBC_1	0.1389
p.R1482Q	SNU-1040	large_intestine	COSMIC	AITTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26010	Integrin beta-7	DEG_SPOP_SBC_1	781:785	AITTT	SPOP	0.9546	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1471:1475	AITTT	SPOP	0.8409	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	559:563	AITTT	SPOP	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AITTT

Degron related mutations and impact score

Drug responses associated with HCFC1 mutations

All proteins holding degron of AITTT