DegronMD

Uniprot ID: P26010

Source protein: Integrin beta-7

Source gene: ITGB7

Class: DEG_SPOP_SBC_1

Location: 781:785

E3 ligase: SPOP

DEGRON score: 0.9546

ASA_SCORE: 58.26

COIL: 0.4164

CONS_SCORE: 0.5595

DSS_SCORE: 0.5029

HELIX: 0.0072

FCONS_SCORE: 1.0906

RIG_SCORE: 0.7761

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R789C	TCGA-12-5295	GBM	TCGA	AITTT	DEG_SPOP_SBC_1	0.2222
p.R789C	TCGA-R6-A8WC	ESCA	TCGA	AITTT	DEG_SPOP_SBC_1	0.2222
p.R789C	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.2222
p.R789C	SIDM00923	Cervical Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.2222
p.P776L	TCGA-5C-A9VG	LIHC	TCGA	AITTT	DEG_SPOP_SBC_1	0.1944
p.R789H	TCGA-D7-8576	STAD	TCGA	AITTT	DEG_SPOP_SBC_1	0.2222
p.R789H	TCGA-F1-6874	STAD	TCGA	AITTT	DEG_SPOP_SBC_1	0.2222
p.S780R	TCGA-EE-A29R	SKCM	TCGA	AITTT	DEG_SPOP_SBC_1	0.75
p.S780N	TCGA-EE-A29R	SKCM	TCGA	AITTT	DEG_SPOP_SBC_1	0.75
p.T783M	SIDM00999	Bladder Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	0.8534
p.T783M	ACH-000973	Bladder Cancer	CCLE	AITTT	DEG_SPOP_SBC_1	0.8534
p.T783M	639-V	urinary_tract	COSMIC	AITTT	DEG_SPOP_SBC_1	0.8534

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26010	Integrin beta-7	DEG_SPOP_SBC_1	781:785	AITTT	SPOP	0.9546	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1471:1475	AITTT	SPOP	0.8409	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	559:563	AITTT	SPOP	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons