DegronMD - P26010(ITGB7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R789C	TCGA-12-5295	GBM	TCGA	AITTT	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2222
p.R789C	TCGA-R6-A8WC	ESCA	TCGA	AITTT	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2222
p.R789C	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2222
p.R789C	SIDM00923	Cervical Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2222
p.P776L	TCGA-5C-A9VG	LIHC	TCGA	AITTT	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.1944
p.R789H	TCGA-D7-8576	STAD	TCGA	AITTT	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2222
p.R789H	TCGA-F1-6874	STAD	TCGA	AITTT	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2222
p.S780R	TCGA-EE-A29R	SKCM	TCGA	AITTT	DEG_SPOP_SBC_1	781:785	Mutation blocking phosphorylation signal	0.75
p.S780N	TCGA-EE-A29R	SKCM	TCGA	AITTT	DEG_SPOP_SBC_1	781:785	Mutation blocking phosphorylation signal	0.75
p.T783M	SIDM00999	Bladder Carcinoma	GDSC	AITTT	DEG_SPOP_SBC_1	781:785	Mutation altering degron motif	0.8534
p.T783M	ACH-000973	Bladder Cancer	CCLE	AITTT	DEG_SPOP_SBC_1	781:785	Mutation altering degron motif	0.8534
p.T783M	639-V	urinary tract	COSMIC	AITTT	DEG_SPOP_SBC_1	781:785	Mutation altering degron motif	0.8534

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons