DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_APCC_KENBOX_2

Location: 1807:1811

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8112

ASA_SCORE: 109.52

COIL: 0.7834

CONS_SCORE: 0.491

DSS_SCORE: 0.4842

HELIX: 0.0678

FCONS_SCORE: 1.046

RIG_SCORE: 0.739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1809Q	TCGA-G7-A8LE	KIRP	TCGA	KKENQ	DEG_APCC_KENBOX_2	0.6744
p.L1800M	DO227996	COCA	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.1389
p.P1801L	DO222532	MELA	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.1667
p.P1798L	SIDM00683	Prostate Carcinoma	GDSC	KKENQ	DEG_APCC_KENBOX_2	0.0833
p.P1798L	ACH-000977	lymph_node	CCLE	KKENQ	DEG_APCC_KENBOX_2	0.0833
p.P1798L	LNCaP-Clone-FGC	prostate	COSMIC	KKENQ	DEG_APCC_KENBOX_2	0.0833
p.M1806I	SIDM00719	Small Cell Lung Carcinoma	GDSC	KKENQ	DEG_APCC_KENBOX_2	0.3056
p.M1806I	SIDM00327	Hodgkin's Lymphoma	GDSC	KKENQ	DEG_APCC_KENBOX_2	0.3056
p.A1804T	SIDM01148	Plasma Cell Myeloma	GDSC	KKENQ	DEG_APCC_KENBOX_2	0.25
p.A1804T	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	KKENQ	DEG_APCC_KENBOX_2	0.25
p.P1811Q	ACH-000573	Breast Cancer	CCLE	KKENQ	DEG_APCC_KENBOX_2	0.7035
p.P1811Q	MDA-MB-436	breast	COSMIC	KKENQ	DEG_APCC_KENBOX_2	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons