DegronMD

Uniprot ID: Q9P2D8

Source protein: Protein unc-79 homolog

Source gene: UNC79

Class: DEG_APCC_KENBOX_2

Location: 55:59

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7769

ASA_SCORE: 107.16

COIL: 0.7864

CONS_SCORE: 0.243

DSS_SCORE: 0.3623

HELIX: 0.1764

FCONS_SCORE: 1.0711

RIG_SCORE: 0.6991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P60Q	TCGA-09-2044	OV	TCGA	KKENQ	DEG_APCC_KENBOX_2	0.3056
p.P60Q	DO28923	OV	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.3056
p.S47L	TCGA-BF-A1PX	SKCM	TCGA	KKENQ	DEG_APCC_KENBOX_2	0.1111
p.S47L	DO51236	SKCM	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.1111
p.P60L	TCGA-BF-AAP2	SKCM	TCGA	KKENQ	DEG_APCC_KENBOX_2	0.3056
p.P60L	DO219466	SKCM	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.3056
p.H63Y	TCGA-EE-A29M	SKCM	TCGA	KKENQ	DEG_APCC_KENBOX_2	0.2222
p.H63Y	DO37404	SKCM	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.2222
p.L64V	DO234348	ESAD	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.1944
p.R52C	DO13510	GBM	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.25
p.I52T	DO228753	LICA	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.25
p.R52H	DO34696	PACA	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.25
p.T65A	DO38404	STAD	ICGC	KKENQ	DEG_APCC_KENBOX_2	0.1667
p.A53T	SIDM00115	Head and Neck Carcinoma	GDSC	KKENQ	DEG_APCC_KENBOX_2	0.2778
p.A53T	ACH-002297	Head and Neck Cancer	CCLE	KKENQ	DEG_APCC_KENBOX_2	0.2778
p.A53T	ACH-002298	Head and Neck Cancer	CCLE	KKENQ	DEG_APCC_KENBOX_2	0.2778
p.A53T	PCI-4B	upper_aerodigestive_tract	COSMIC	KKENQ	DEG_APCC_KENBOX_2	0.2778
p.A53T	PCI-6A	upper_aerodigestive_tract	COSMIC	KKENQ	DEG_APCC_KENBOX_2	0.2778
p.G54W	ACH-000945	Lung Cancer	CCLE	KKENQ	DEG_APCC_KENBOX_2	0.3056
p.S58F	Sarc9371	bone	COSMIC	KKENQ	DEG_APCC_KENBOX_2	0.7982
p.E68K	Sarc9371	bone	COSMIC	KKENQ	DEG_APCC_KENBOX_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons