DegronMD - Q9P2D8(UNC79)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1691N	TCGA-06-5416	GBM	TCGA	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.0833
p.D1691N	DO10880	GBM	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.0833
p.P60Q	TCGA-09-2044	OV	TCGA	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.P60Q	DO28923	OV	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.I1908M	TCGA-17-Z026	LUAD	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.2222
p.F1909L	TCGA-18-3411	LUSC	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.25
p.F1909L	DO26758	LUSC	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.25
p.G1916S	TCGA-AP-A1DH	UCEC	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6993
p.G1916S	TCGA-BR-4184	STAD	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6993
p.G1916S	DO38328	STAD	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6993
p.G1916S	DO43995	UCEC	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6993
p.S47L	TCGA-BF-A1PX	SKCM	TCGA	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1111
p.S47L	DO51236	SKCM	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1111
p.P60L	TCGA-BF-AAP2	SKCM	TCGA	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.P60L	DO219466	SKCM	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.R1906C	TCGA-D5-6536	COAD	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1667
p.R1906C	DO8200	COAD	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1667
p.R1906C	DO222765	COCA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1667
p.R1706P	TCGA-E2-A10C	BRCA	TCGA	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation altering degron motif	0.7512
p.R1706P	DO1334	BRCA	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation altering degron motif	0.7512
p.H63Y	TCGA-EE-A29M	SKCM	TCGA	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2222
p.H63Y	DO37404	SKCM	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2222
p.Q1911R	TCGA-EE-A2GR	SKCM	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.3056
p.Q1911R	DO37996	SKCM	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.3056
p.A1913V	TCGA-EO-A22X	UCEC	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6936
p.A1913V	DO43907	UCEC	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6936
p.F1904L	TCGA-GU-AATP	BLCA	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1111
p.F1904L	DO51894	BLCA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1111
p.L64V	DO234348	ESAD	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1944
p.A1711V	DO233156	GACA	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.1944
p.R52C	DO13510	GBM	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.25
p.N1915Y	DO228574	LICA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.7059
p.I52T	DO228753	LICA	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.25
p.G1929E	DO220891	MELA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.0833
p.S1700L	DO220911	MELA	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation altering degron motif	0.7667
p.R52H	DO34696	PACA	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.25
p.G1916D	DO228138	PBCA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.7198
p.P1694S	DO229456	SKCA	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation substituting flanking lysine	0.2778
p.N1915H	DO218886	SKCA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.7423
p.T65A	DO38404	STAD	ICGC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1667
p.A53T	SIDM00115	Head and Neck Carcinoma	GDSC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2778
p.A53T	ACH-002297	Head and Neck Cancer	CCLE	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2778
p.A53T	ACH-002298	Head and Neck Cancer	CCLE	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2778
p.A53T	PCI-4B	upper aerodigestive tract	COSMIC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2778
p.A53T	PCI-6A	upper aerodigestive tract	COSMIC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2778
p.G1929W	SIDM01503	Small Cell Lung Carcinoma	GDSC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.0833
p.G1929W	ACH-000844	Lung Cancer	CCLE	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.0833
p.T1713K	SIDM01588	Endometrial Carcinoma	GDSC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.1389
p.T1713K	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.1389
p.G1698R	SIDM01750	Melanoma	GDSC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.2778
p.G1698R	ACH-000801	Skin Cancer	CCLE	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.2778
p.G54W	ACH-000945	Lung Cancer	CCLE	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.R1706Q	ACH-001973	Metastasis	CCLE	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation altering degron motif	0.7329
p.V1917L	SCH	stomach	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6765
p.T1710I	NUGC-3	stomach	COSMIC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.2222
p.S1915Y	NCI-H510A	lung	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.712
p.T1703I	CAL-12T	lung	COSMIC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation altering degron motif	0.7078
p.G1911E	Mewo	skin	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.3056
p.S58F	Sarc9371	bone	COSMIC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation altering degron motif	0.7982
p.S1925L	HT-1197	urinary tract	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1944
p.E68K	Sarc9371	bone	COSMIC	KKENQ	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.0833
p.Q1909H	T84	large intestine	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.25
p.P1696T	HO-1-u-1	upper aerodigestive tract	COSMIC	DSGNNQS	DEG_SCF_TRCP1_1	1700:1706	Mutation rewiring degron network	0.2222
p.S1903L	HT-1197	urinary tract	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.0833
p.S1905P	ESS-1	endometrium	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1389
p.G1911R	Mewo	skin	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.3056
p.G1914E	KMH-2	thyroid	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6087
p.S1927P	ESS-1	endometrium	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1389
p.P1910H	SNU-175	large intestine	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.2778
p.G1917E	CP50-MEL-B	skin	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6087
p.P1923S	NCI-H2030	lung	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNC79

UniProt ID: Q9P2D8

Entrez ID: 57578

Protein name: Protein unc-79 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNC79 in