DegronMD

Uniprot ID: Q9P2D8

Source protein: Protein unc-79 homolog

Source gene: UNC79

Class: DEG_SCF_TRCP1_1

Location: 1700:1706

E3 ligase: BTRC

DEGRON score: 0.9612

ASA_SCORE: 94.4286

COIL: 0.9469

CONS_SCORE: 0.2975

DSS_SCORE: 0.6163

HELIX: 0.0346

FCONS_SCORE: 0.9457

RIG_SCORE: 0.5837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1691N	TCGA-06-5416	GBM	TCGA	DSGNNQS	DEG_SCF_TRCP1_1	0.0833
p.D1691N	DO10880	GBM	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	0.0833
p.R1706P	TCGA-E2-A10C	BRCA	TCGA	DSGNNQS	DEG_SCF_TRCP1_1	0.7512
p.R1706P	DO1334	BRCA	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	0.7512
p.A1711V	DO233156	GACA	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	0.1944
p.S1700L	DO220911	MELA	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	0.7667
p.P1694S	DO229456	SKCA	ICGC	DSGNNQS	DEG_SCF_TRCP1_1	0.2778
p.T1713K	SIDM01588	Endometrial Carcinoma	GDSC	DSGNNQS	DEG_SCF_TRCP1_1	0.1389
p.T1713K	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGNNQS	DEG_SCF_TRCP1_1	0.1389
p.G1698R	SIDM01750	Melanoma	GDSC	DSGNNQS	DEG_SCF_TRCP1_1	0.2778
p.G1698R	ACH-000801	Skin Cancer	CCLE	DSGNNQS	DEG_SCF_TRCP1_1	0.2778
p.R1706Q	ACH-001973	Metastasis	CCLE	DSGNNQS	DEG_SCF_TRCP1_1	0.7329
p.T1710I	NUGC-3	stomach	COSMIC	DSGNNQS	DEG_SCF_TRCP1_1	0.2222
p.T1703I	CAL-12T	lung	COSMIC	DSGNNQS	DEG_SCF_TRCP1_1	0.7078
p.P1696T	HO-1-u-1	upper_aerodigestive_tract	COSMIC	DSGNNQS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2D8	Protein unc-79 homolog	DEG_SCF_TRCP1_1	1700:1706	DSGNNQS	BTRC	0.9612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons