DegronMD

Uniprot ID: Q9P2D8

Source protein: Protein unc-79 homolog

Source gene: UNC79

Class: DEG_APCC_DBOX_1

Location: 1912:1920

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9128

ASA_SCORE: 93.3

COIL: 0.8693

CONS_SCORE: 0.3094

DSS_SCORE: 0.4835

HELIX: 0.0569

FCONS_SCORE: 1.006

RIG_SCORE: 0.7295

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1908M	TCGA-17-Z026	LUAD	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	0.2222
p.F1909L	TCGA-18-3411	LUSC	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	0.25
p.F1909L	DO26758	LUSC	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.25
p.G1916S	TCGA-AP-A1DH	UCEC	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	0.6993
p.G1916S	TCGA-BR-4184	STAD	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	0.6993
p.G1916S	DO38328	STAD	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.6993
p.G1916S	DO43995	UCEC	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.6993
p.R1906C	TCGA-D5-6536	COAD	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	0.1667
p.R1906C	DO8200	COAD	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.1667
p.R1906C	DO222765	COCA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.1667
p.Q1911R	TCGA-EE-A2GR	SKCM	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	0.3056
p.Q1911R	DO37996	SKCM	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.3056
p.A1913V	TCGA-EO-A22X	UCEC	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	0.6936
p.A1913V	DO43907	UCEC	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.6936
p.F1904L	TCGA-GU-AATP	BLCA	TCGA	KRGSLGVLT	DEG_APCC_DBOX_1	0.1111
p.F1904L	DO51894	BLCA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.1111
p.N1915Y	DO228574	LICA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.7059
p.G1929E	DO220891	MELA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.0833
p.G1916D	DO228138	PBCA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.7198
p.N1915H	DO218886	SKCA	ICGC	KRGSLGVLT	DEG_APCC_DBOX_1	0.7423
p.G1929W	SIDM01503	Small Cell Lung Carcinoma	GDSC	KRGSLGVLT	DEG_APCC_DBOX_1	0.0833
p.G1929W	ACH-000844	Lung Cancer	CCLE	KRGSLGVLT	DEG_APCC_DBOX_1	0.0833
p.V1917L	SCH	stomach	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.6765
p.S1915Y	NCI-H510A	lung	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.712
p.G1911E	Mewo	skin	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.3056
p.S1925L	HT-1197	urinary_tract	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.1944
p.Q1909H	T84	large_intestine	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.25
p.S1903L	HT-1197	urinary_tract	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.0833
p.S1905P	ESS-1	endometrium	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.1389
p.G1911R	Mewo	skin	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.3056
p.G1914E	KMH-2	thyroid	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.6087
p.S1927P	ESS-1	endometrium	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.1389
p.P1910H	SNU-175	large_intestine	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.2778
p.G1917E	CP50-MEL-B	skin	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.6087
p.P1923S	NCI-H2030	lung	COSMIC	KRGSLGVLT	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRGSLGVLT

Degron related mutations and impact score

Drug responses associated with UNC79 mutations

All proteins holding degron of KRGSLGVLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2D8	Protein unc-79 homolog	DEG_APCC_DBOX_1	1912:1920	KRGSLGVLT	APC,CDC20,FZR1	0.9128	More...