DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_SCF_FBW7_1

Location: 580:587

E3 ligase: FBXW7

DEGRON score: 0.9266

ASA_SCORE: 91.3875

COIL: 0.9011

CONS_SCORE: 0.5122

DSS_SCORE: 0.3239

HELIX: 0.0139

FCONS_SCORE: 1.0852

RIG_SCORE: 0.7662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A591V	DO224577	BRCA	ICGC	MAVTPGTT	DEG_SCF_FBW7_1	0.2222
p.M580V	DO233267	GACA	ICGC	MAVTPGTT	DEG_SCF_FBW7_1	0.6097
p.P571Q	DO229303	LMS	ICGC	MAVTPGTT	DEG_SCF_FBW7_1	0.0833
p.L589F	DO222868	MELA	ICGC	MAVTPGTT	DEG_SCF_FBW7_1	0.2778
p.P590T	SIDM01943	Colorectal Carcinoma	GDSC	MAVTPGTT	DEG_SCF_FBW7_1	0.25
p.G585S	ACH-000436	Myeloma	CCLE	MAVTPGTT	DEG_SCF_FBW7_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51610	Host cell factor 1	DEG_SCF_FBW7_1	580:587	MAVTPGTT	FBXW7	0.9266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons