DegronMD

Uniprot ID: Q6ZS17

Source protein: Rho family-interacting cell polarization regulator 1

Source gene: RIPOR1

Class: DEG_SCF_FBW7_1

Location: 726:732

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 101.1143

COIL: 0.9664

CONS_SCORE: 0.2801

DSS_SCORE: 0.8001

HELIX: 0.013

FCONS_SCORE: 0.9947

RIG_SCORE: 0.5077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A730T	HCT-116	large_intestine	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	0.7139
p.S733N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	0.3056
p.S737N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	0.1944
p.S739N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	0.25
p.A734T	HCT-116	large_intestine	COSMIC	PRTPHPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SCF_FBW7_1	726:732	PRTPHPS	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons