DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VPTST
Uniprot ID:
Q6ZS17
Source protein:
Rho family-interacting cell polarization regulator 1
Source gene:
RIPOR1
Class:
DEG_SPOP_SBC_1
Location:
519:523
E3 ligase:
SPOP
DEGRON score:
0.6443
ASA_SCORE:
92.06
COIL:
0.9612
CONS_SCORE:
0.233
DSS_SCORE:
0.7247
HELIX:
0.0114
FCONS_SCORE:
0.8951
RIG_SCORE:
0.5865
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RIPOR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P29401
Transketolase
DEG_SPOP_SBC_1
440:444
VPTST
SPOP
0.7263
More...
P51843
Nuclear receptor subfamily 0 group B member 1
DEG_SPOP_SBC_1
216:220
VPTST
SPOP
0.6965
More...
P55199
RNA polymerase II elongation factor ELL
DEG_SPOP_SBC_1
499:503
VPTST
SPOP
0.8985
More...
Q01668
Voltage-dependent L-type calcium channel subunit alpha-1D
DEG_SPOP_SBC_1
1750:1754
VPTST
SPOP
0.9683
More...
Q6ZS17
Rho family-interacting cell polarization regulator 1
DEG_SPOP_SBC_1
519:523
VPTST
SPOP
0.6443
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
2415:2419
VPTST
SPOP
0.8829
More...
Q9H0M0
NEDD4-like E3 ubiquitin-protein ligase WWP1
DEG_SPOP_SBC_1
193:197
VPTST
SPOP
0.9832
More...
Q9H4A3
Serine/threonine-protein kinase WNK1
DEG_SPOP_SBC_1
1433:1437
VPTST
SPOP
0.9542
More...