DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 2415:2419

E3 ligase: SPOP

DEGRON score: 0.8829

ASA_SCORE: 87.38

COIL: 0.9396

CONS_SCORE: 0

DSS_SCORE: 0.6707

HELIX: 0.0124

FCONS_SCORE: 0

RIG_SCORE: 0.6328

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2414P	TCGA-2W-A8YY	CESC	TCGA	VPTST	DEG_SPOP_SBC_1	0.3056
p.Q2414P	DO223732	CESC	ICGC	VPTST	DEG_SPOP_SBC_1	0.3056
p.T2422K	TCGA-44-5644	LUAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.25
p.T2422K	DO25153	LUAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.25
p.L2407I	TCGA-55-7281	LUAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.1111
p.L2407I	DO25985	LUAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.1111
p.Q2414K	TCGA-A4-7583	KIRP	TCGA	VPTST	DEG_SPOP_SBC_1	0.3056
p.Q2414K	DO20870	KIRP	ICGC	VPTST	DEG_SPOP_SBC_1	0.3056
p.A2425T	TCGA-AA-A00N	COAD	TCGA	VPTST	DEG_SPOP_SBC_1	0.1667
p.A2425T	TCGA-ER-A194	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	0.1667
p.A2425T	DO9876	COAD	ICGC	VPTST	DEG_SPOP_SBC_1	0.1667
p.A2425T	DO47646	SKCM	ICGC	VPTST	DEG_SPOP_SBC_1	0.1667
p.S2427F	TCGA-AG-A002	READ	TCGA	VPTST	DEG_SPOP_SBC_1	0.1111
p.E2421K	TCGA-AX-A05Z	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.2778
p.E2421K	DO40884	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.2778
p.L2407F	TCGA-BS-A0UV	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	0.1111
p.L2407F	DO42793	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	0.1111
p.P2416S	TCGA-EB-A6QY	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	0.5641
p.P2416S	DO48702	SKCM	ICGC	VPTST	DEG_SPOP_SBC_1	0.5641
p.S2406F	TCGA-EE-A20C	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	0.0833
p.S2406F	DO222775	MELA	ICGC	VPTST	DEG_SPOP_SBC_1	0.0833
p.S2406F	DO47665	SKCM	ICGC	VPTST	DEG_SPOP_SBC_1	0.0833
p.N2423T	TCGA-MI-A75C	LIHC	TCGA	VPTST	DEG_SPOP_SBC_1	0.2222
p.N2423T	DO49705	LIHC	ICGC	VPTST	DEG_SPOP_SBC_1	0.2222
p.P2405Q	DO228929	LICA	ICGC	VPTST	DEG_SPOP_SBC_1	0.0556
p.S2409P	DO229183	NKTL	ICGC	VPTST	DEG_SPOP_SBC_1	0.1667
p.P2413T	SIDM00087	Plasma Cell Myeloma	GDSC	VPTST	DEG_SPOP_SBC_1	0.2778
p.P2413T	SIDM00529	Breast Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.2778
p.P2413T	SIDM00879	Breast Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.2778
p.P2413T	SIDM00882	Breast Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.2778
p.P2413T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29401	Transketolase	DEG_SPOP_SBC_1	440:444	VPTST	SPOP	0.7263	More...
P51843	Nuclear receptor subfamily 0 group B member 1	DEG_SPOP_SBC_1	216:220	VPTST	SPOP	0.6965	More...
P55199	RNA polymerase II elongation factor ELL	DEG_SPOP_SBC_1	499:503	VPTST	SPOP	0.8985	More...
Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	DEG_SPOP_SBC_1	1750:1754	VPTST	SPOP	0.9683	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	519:523	VPTST	SPOP	0.6443	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2415:2419	VPTST	SPOP	0.8829	More...
Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	DEG_SPOP_SBC_1	193:197	VPTST	SPOP	0.9832	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1433:1437	VPTST	SPOP	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VPTST