NR0B1
UniProt ID: P51843
Entrez ID: 190
Protein name: Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in ...
FUNCTION: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
adrenal gland development [GO:0030325]; gonad development [GO:0008406]; hypothalamus development [GO:0021854]; Leydig cell differentiation [GO:0033327]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of DNA-binding transcription factor activity [GO:0043...
adrenal gland development [GO:0030325]; gonad development [GO:0008406]; hypothalamus development [GO:0021854]; Leydig cell differentiation [GO:0033327]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pituitary gland development [GO:0021983]; protein localization [GO:0008104]; response to immobilization stress [GO:0035902]; Sertoli cell differentiation [GO:0060008]; spermatogenesis [GO:0007283]
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GO - Molecular function (MF):
AF-2 domain binding [GO:0050682]; DNA hairpin binding [GO:0032448]; nuclear receptor binding [GO:0016922]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0...
AF-2 domain binding [GO:0050682]; DNA hairpin binding [GO:0032448]; nuclear receptor binding [GO:0016922]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]
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GO - Cellular component (CC):
centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]...
centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]
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NR0B1
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Kaplan plot for NR0B1 in
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*NOTE: the Kaplan plots were collected from OncoLnc