DegronMD

Uniprot ID: Q9H0M0

Source protein: NEDD4-like E3 ubiquitin-protein ligase WWP1

Source gene: WWP1

Class: DEG_SCF_FBW7_1

Location: 257:264

E3 ligase: FBXW7

DEGRON score: 0.9834

ASA_SCORE: 81.3

COIL: 0.9143

CONS_SCORE: 0.4342

DSS_SCORE: 0.6084

HELIX: 0.0295

FCONS_SCORE: 1.0068

RIG_SCORE: 0.6866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D253Y	TCGA-69-8253	LUAD	TCGA	VTGTPVVS	DEG_SCF_FBW7_1	0.2222
p.A268V	TCGA-85-6560	LUSC	TCGA	VTGTPVVS	DEG_SCF_FBW7_1	0.2222
p.N272K	TCGA-EJ-8474	PRAD	TCGA	VTGTPVVS	DEG_SCF_FBW7_1	0.1111
p.S264C	TCGA-WQ-AB4B	LIHC	TCGA	VTGTPVVS	DEG_SCF_FBW7_1	0.7541
p.P255L	DO48576	BLCA	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.2778
p.R266S	DO477	BLCA	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.2778
p.R264H	DO223732	CESC	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.8244
p.R264H	DO229050	LICA	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.8244
p.R266I	DO222798	COCA	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.2778
p.P255T	DO14282	HNSC	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.2778
p.E248D	DO218940	LUAD	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.0833
p.H272R	DO45410	LUAD	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.1111
p.Y268H	DO45314	LUAD	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.2222
p.R265K	DO37442	SKCM	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.3056
p.V261A	DO43274	UCEC	ICGC	VTGTPVVS	DEG_SCF_FBW7_1	0.6936
p.V257I	SIDM00683	Prostate Carcinoma	GDSC	VTGTPVVS	DEG_SCF_FBW7_1	0.5965
p.V257I	ACH-000977	lymph_node	CCLE	VTGTPVVS	DEG_SCF_FBW7_1	0.5965
p.V257I	LNCaP-Clone-FGC	prostate	COSMIC	VTGTPVVS	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	DEG_SCF_FBW7_1	257:264	VTGTPVVS	FBXW7	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons