DegronMD - Q5VWP3(MLIP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S404L	TCGA-04-1336	OV	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1944
p.R160L	TCGA-17-Z016	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.P400Q	TCGA-49-AAR2	LUAD	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.0833
p.D173N	TCGA-55-8205	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.D173N	DO48884	LUAD	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.Q401E	TCGA-61-2104	OV	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1111
p.L170M	TCGA-78-7155	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.I166F	TCGA-96-8170	LUSC	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6304
p.R176C	TCGA-A5-A0G2	UCEC	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.S428Y	TCGA-AA-3510	COAD	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1389
p.E426D	TCGA-AG-A002	READ	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1944
p.E426D	TCGA-EY-A1GI	UCEC	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1944
p.R160W	TCGA-CG-5726	STAD	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R160W	DO23108	LINC	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R160W	DO45041	LINC	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R160W	DO38483	STAD	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R160W	ACH-000874	Leukemia	CCLE	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R160W	RS4-11	haematopoietic and lymphoid tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R176H	TCGA-CM-5861	COAD	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.P413L	TCGA-D3-A2JF	SKCM	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.6471
p.H429Y	TCGA-D3-A8GI	SKCM	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1111
p.L403F	TCGA-EE-A2GJ	SKCM	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1667
p.L403F	ACH-000768	Breast Cancer	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1667
p.L403F	MDA-MB-231	breast	COSMIC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1667
p.H416Q	TCGA-FI-A2D5	UCEC	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.647
p.G412R	TCGA-IB-7651	PAAD	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.6457
p.T402I	TCGA-OR-A5JP	ACC	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1389
p.S167L	TCGA-W3-A825	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7667
p.S168F	TCGA-WE-AAA0	SKCM	TCGA	AISSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7982
p.P177S	DO48390	BLCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.D173G	DO48370	BLCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.Q417E	DO225215	BRCA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.6744
p.Q417E	DO227836	BRCA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.6744
p.R170H	DO7918	COAD	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.R170H	DO51025	LAML	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.S164T	DO229010	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.S164T	DO229013	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.S164T	DO229016	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.S164T	DO229003	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.S164T	DO229005	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.V159I	DO229010	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.V159I	DO229013	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.V159I	DO229016	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.V159I	DO229003	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.V159I	DO229005	COCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.V159I	DO229028	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.G155C	DO233808	GACA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.A404S	DO228952	LICA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.1944
p.S421F	DO222542	MELA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.7982
p.S424F	DO222868	MELA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.25
p.S424F	ACH-001982	Metastasis	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.25
p.P414S	DO229459	SKCA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.6752
p.T166K	DO229229	THCA	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7306
p.R418I	DO50076	UCEC	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.8102
p.V177L	DO42312	UCEC	ICGC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.F420L	DO43049	UCEC	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation altering degron motif	0.6981
p.G163R	SIDM00373	Endometrial Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	SIDM00496	Thyroid Gland Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	SIDM00489	Oral Cavity Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	SIDM01061	Oral Cavity Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	SIDM00160	Biliary Tract Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	HTC-C3	thyroid	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	SNG-M	endometrium	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	PC-3_[JPC-3]	lung	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	TE-9	oesophagus	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	HN	upper aerodigestive tract	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163R	Ca9-22	upper aerodigestive tract	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163V	SIDM00690	Head and Neck Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163V	SIDM00210	Ovarian Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163V	SIDM00879	Breast Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163V	SIDM00954	Breast Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163V	SIDM00785	Acute Myeloid Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G163V	SIDM01387	Small Cell Lung Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.G160S	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.G160S	SK-LU-1	lung	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.G166S	SIDM00999	Bladder Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6993
p.G166S	639-V	urinary tract	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6993
p.R171W	SIDM01086	B-Lymphoblastic Leukemia	GDSC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.R171W	RS4-11	haematopoietic and lymphoid tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.E424K	ACH-000835	Sarcoma	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.25
p.E424K	GCT	soft tissue	COSMIC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.25
p.G155S	ACH-000973	Bladder Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.G155S	639-V	urinary tract	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.L406V	ACH-001393	Breast Cancer	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.25
p.L406R	ACH-001959	Bile Duct Cancer	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	409:421	Mutation rewiring degron network	0.25
p.P158L	MCC13	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.D166N	COLO-783	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6932
p.D166V	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	AISSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7785

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLIP

UniProt ID: Q5VWP3

Entrez ID: 90523

Protein name: Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MLIP in