DegronMD

Uniprot ID: Q5VWP3

Source protein: Muscular LMNA-interacting protein

Source gene: MLIP

Class: DEG_ODPH_VHL_1

Location: 409:421

E3 ligase: VHL

DEGRON score: 0.5782

ASA_SCORE: 65.1077

COIL: 0.7601

CONS_SCORE: 0.5556

DSS_SCORE: 0.3267

HELIX: 0.1205

FCONS_SCORE: 1.1465

RIG_SCORE: 0.6855

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S404L	TCGA-04-1336	OV	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1944
p.P400Q	TCGA-49-AAR2	LUAD	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.0833
p.Q401E	TCGA-61-2104	OV	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1111
p.S428Y	TCGA-AA-3510	COAD	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1389
p.E426D	TCGA-AG-A002	READ	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1944
p.E426D	TCGA-EY-A1GI	UCEC	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1944
p.P413L	TCGA-D3-A2JF	SKCM	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.6471
p.H429Y	TCGA-D3-A8GI	SKCM	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1111
p.L403F	TCGA-EE-A2GJ	SKCM	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1667
p.L403F	ACH-000768	Breast Cancer	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1667
p.L403F	MDA-MB-231	breast	COSMIC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1667
p.H416Q	TCGA-FI-A2D5	UCEC	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.647
p.G412R	TCGA-IB-7651	PAAD	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.6457
p.T402I	TCGA-OR-A5JP	ACC	TCGA	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1389
p.Q417E	DO225215	BRCA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.6744
p.Q417E	DO227836	BRCA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.6744
p.A404S	DO228952	LICA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.1944
p.S421F	DO222542	MELA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.7982
p.S424F	DO222868	MELA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.25
p.S424F	ACH-001982	Metastasis	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.25
p.P414S	DO229459	SKCA	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.6752
p.R418I	DO50076	UCEC	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.8102
p.F420L	DO43049	UCEC	ICGC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.6981
p.E424K	ACH-000835	Sarcoma	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.25
p.E424K	GCT	soft_tissue	COSMIC	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.25
p.L406V	ACH-001393	Breast Cancer	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.25
p.L406R	ACH-001959	Bile Duct Cancer	CCLE	LAPGPFSHLSFSL	DEG_ODPH_VHL_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGPFSHLSFSL

Degron related mutations and impact score

Drug responses associated with MLIP mutations

All proteins holding degron of LAPGPFSHLSFSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWP3	Muscular LMNA-interacting protein	DEG_ODPH_VHL_1	409:421	LAPGPFSHLSFSL	VHL	0.5782	More...