DegronMD

Uniprot ID: Q8IV76

Source protein: Circadian clock protein PASD1

Source gene: PASD1

Class: LIG_APCC_ABBA_1

Location: 256:261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5307

ASA_SCORE: 59.8833

COIL: 0.1917

CONS_SCORE: 0.8472

DSS_SCORE: 0.3949

HELIX: 0.0217

FCONS_SCORE: 0.8947

RIG_SCORE: 0.795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S262Y	TCGA-19-5954	GBM	TCGA	VHMFVD	LIG_APCC_ABBA_1	0.3056
p.S262Y	DO11459	GBM	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.3056
p.Y250D	TCGA-91-6828	LUAD	TCGA	VHMFVD	LIG_APCC_ABBA_1	0.1667
p.Y250D	DO26150	LUAD	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.1667
p.E254D	TCGA-A5-A0GP	UCEC	TCGA	VHMFVD	LIG_APCC_ABBA_1	0.2778
p.E254D	DO41109	UCEC	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.2778
p.E254K	TCGA-AP-A1DV	UCEC	TCGA	VHMFVD	LIG_APCC_ABBA_1	0.2778
p.E254K	DO43186	UCEC	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.2778
p.Q249R	TCGA-C8-A12V	BRCA	TCGA	VHMFVD	LIG_APCC_ABBA_1	0.1389
p.Q249R	DO4044	BRCA	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.1389
p.S262F	TCGA-EE-A3JD	SKCM	TCGA	VHMFVD	LIG_APCC_ABBA_1	0.3056
p.S262F	DO50299	SKCM	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.3056
p.T270R	TCGA-HC-A6HX	PRAD	TCGA	VHMFVD	LIG_APCC_ABBA_1	0.0833
p.T270R	DO46806	PRAD	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.0833
p.Y266H	DO233688	GACA	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.1944
p.S264L	DO220906	MELA	ICGC	VHMFVD	LIG_APCC_ABBA_1	0.25
p.N255I	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VHMFVD	LIG_APCC_ABBA_1	0.3056
p.N255I	ACH-000860	Lung Cancer	CCLE	VHMFVD	LIG_APCC_ABBA_1	0.3056
p.N255I	NCI-H358	lung	COSMIC	VHMFVD	LIG_APCC_ABBA_1	0.3056
p.D261Y	SIDM01588	Endometrial Carcinoma	GDSC	VHMFVD	LIG_APCC_ABBA_1	0.7325
p.D261Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	VHMFVD	LIG_APCC_ABBA_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV76	Circadian clock protein PASD1	LIG_APCC_ABBA_1	256:261	VHMFVD	APC,CDC20,FZR1	0.5307	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons