DegronMD

Uniprot ID: Q9H2X6

Source protein: Homeodomain-interacting protein kinase 2

Source gene: HIPK2

Class: DEG_SPOP_SBC_1

Location: 903:907

E3 ligase: SPOP

DEGRON score: 0.9701

ASA_SCORE: 75.04

COIL: 0.8756

CONS_SCORE: 0.3269

DSS_SCORE: 0.6546

HELIX: 0.1062

FCONS_SCORE: 0.9304

RIG_SCORE: 0.6856

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E897G	TCGA-02-2483	GBM	TCGA	APTST	DEG_SPOP_SBC_1	0.1667
p.E897G	DO12352	GBM	ICGC	APTST	DEG_SPOP_SBC_1	0.1667
p.E898K	TCGA-A3-3378	KIRC	TCGA	APTST	DEG_SPOP_SBC_1	0.1944
p.E896D	TCGA-AA-3492	COAD	TCGA	APTST	DEG_SPOP_SBC_1	0.1389
p.E896D	TCGA-EY-A215	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	0.1389
p.E896D	DO8224	COAD	ICGC	APTST	DEG_SPOP_SBC_1	0.1389
p.E896D	DO233109	GACA	ICGC	APTST	DEG_SPOP_SBC_1	0.1389
p.E896D	DO42665	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	0.1389
p.D895G	TCGA-BR-4361	STAD	TCGA	APTST	DEG_SPOP_SBC_1	0.1111
p.D895G	DO38887	STAD	ICGC	APTST	DEG_SPOP_SBC_1	0.1111
p.A903V	DO233903	GACA	ICGC	APTST	DEG_SPOP_SBC_1	0.5825
p.T894K	DO228952	LICA	ICGC	APTST	DEG_SPOP_SBC_1	0.0833
p.S900Y	DO229029	LICA	ICGC	APTST	DEG_SPOP_SBC_1	0.25
p.L899I	DO229028	LICA	ICGC	APTST	DEG_SPOP_SBC_1	0.2222
p.H902Q	DO229037	LICA	ICGC	APTST	DEG_SPOP_SBC_1	0.3056
p.E899K	DO50904	LICA	ICGC	APTST	DEG_SPOP_SBC_1	0.2222
p.E896K	SIDM00217	Colorectal Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.1389
p.E896K	ACH-000999	Colon/Colorectal Cancer	CCLE	APTST	DEG_SPOP_SBC_1	0.1389
p.E896K	SNU-1040	large_intestine	COSMIC	APTST	DEG_SPOP_SBC_1	0.1389
p.N914K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	APTST	DEG_SPOP_SBC_1	0.1389
p.N914K	ACH-001127	Leukemia	CCLE	APTST	DEG_SPOP_SBC_1	0.1389
p.N914K	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	APTST	DEG_SPOP_SBC_1	0.1389
p.T894A	ACH-001063	Ovarian Cancer	CCLE	APTST	DEG_SPOP_SBC_1	0.0833
p.R914C	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	APTST	DEG_SPOP_SBC_1	0.1389

Drug responses associated with HIPK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E136D (No)	GDSC	PI-103	186.6479
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D502N (No)	GDSC	PI-103	1.081
SIDM00951	LAML\|acute_myeloid_leukaemia	p.I227T (No)	GDSC	PI-103	1.081
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1184V (No)	GDSC	PI-103	0.1231
SIDM00680	COREAD\|large_intestine	p.R554Q (No)	GDSC	PI-103	131.335
SIDM01045	UCEC\|endometrium	p.L59fs*56 (No)	GDSC	PI-103	3.7811
SIDM00499	PRAD\|prostate	p.G45D (No)	GDSC	PI-103	0.3537
SIDM00145	ALL\|lymphoblastic_leukemia	p.N914K (Yes)	GDSC	PI-103	0.1685
SIDM00108	SKCM\|melanoma	p.H322Q (No)	GDSC	PI-103	2.1752
SIDM00351	HNSC\|head_and_neck	p.R868W (No)	GDSC	PI-103	1.0036
SIDM00976	SKCM\|melanoma	p.G348R (No)	GDSC	PI-103	0.2229
SIDM00045	STAD\|stomach	p.C658F (No)	GDSC	PI-103	0.7557
SIDM01107	SKCM\|melanoma	p.T602P (No)	GDSC	PI-103	57.4273
SIDM01007	ALL\|lymphoblastic_leukemia	p.H807R (No)	GDSC	PI-103	0.2023
SIDM01007	ALL\|lymphoblastic_leukemia	p.K805R (No)	GDSC	PI-103	0.2023
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.S142N (No)	GDSC	PI-103	0.2031
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.H760R (No)	GDSC	PI-103	2.0651
SIDM00565	HNSC\|head_and_neck	p.V737M (No)	GDSC	PI-103	2.2952
SIDM00443	DLBC\|B_cell_lymphoma	p.R941C (No)	GDSC	PI-103	0.0219
SIDM00377	UNCLASSIFIED\|uterus	p.H540R (No)	GDSC	PI-103	2.6284
SIDM00498	COREAD\|large_intestine	p.I603V (No)	GDSC	PI-103	3.2887
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.A624V (No)	GDSC	PI-103	0.0783
SIDM01045	UCEC\|endometrium	p.V94E (No)	GDSC	PI-103	3.7811
SIDM00946	ALL\|T_cell_leukemia	p.V50M (No)	GDSC	PI-103	0.526
SIDM00864	CESC\|cervix	p.I875V (No)	GDSC	PI-103	23.1182
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.R433S (No)	GDSC	PI-103	131.0205
SIDM00217	COREAD\|large_intestine	p.A1178V (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.E896K (Yes)	GDSC	PI-103	1.8634
SIDM01003	ALL\|lymphoblastic_leukemia	p.R497Q (No)	GDSC	PI-103	0.2158
SIDM00216	COREAD\|large_intestine	p.I146T (No)	GDSC	PI-103	20.9452
SIDM00596	UCEC\|endometrium	p.R498Q (No)	GDSC	PI-103	22.6646
SIDM00282	COREAD\|large_intestine	p.A719S (No)	GDSC	PI-103	28.6572
SIDM00660	COREAD\|large_intestine	p.A512V (No)	GDSC	PI-103	0.5852
SIDM00955	SKCM\|melanoma	p.T1022N (No)	GDSC	PI-103	14.8056
SIDM00783	COREAD\|large_intestine	p.R792W (No)	GDSC	PI-103	0.5867
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I33V (No)	GDSC	PI-103	0.0974
SIDM00789	COREAD\|large_intestine	p.V67I (No)	GDSC	PI-103	0.8427
SIDM00534	COREAD\|large_intestine	p.V1121A (No)	GDSC	PI-103	137.3337
SIDM00149	SKCM\|melanoma	p.M635I (No)	GDSC	PI-103	3.9173
SIDM00545	SKCM\|melanoma	p.R1056Q (No)	GDSC	PI-103	9.7833
SIDM00545	SKCM\|melanoma	p.H524Y (No)	GDSC	PI-103	9.7833
SIDM00114	MESO\|mesothelioma	p.L716I (No)	GDSC	PI-103	6.8017
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R133H (No)	GDSC	PI-103	0.976
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L108F (No)	GDSC	PI-103	0.2536
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S317I (No)	GDSC	PI-103	17.6642
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.F500V (No)	GDSC	PI-103	1.0649
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y468N (No)	GDSC	PI-103	1.0649
SIDM00537	COREAD\|large_intestine	p.T125A (No)	GDSC	PI-103	32.6383
SIDM00799	GBM\|glioma	p.S1002Y (No)	GDSC	PI-103	54.1746
SIDM00496	THCA\|thyroid	p.Q747K (No)	GDSC	PI-103	0.4742
SIDM00878	BRCA\|breast	p.R833C (No)	GDSC	PI-103	0.1835

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15068	Guanine nucleotide exchange factor DBS	DEG_SPOP_SBC_1	970:974	APTST	SPOP	0.8568	More...
O15446	DNA-directed RNA polymerase I subunit RPA34	DEG_SPOP_SBC_1	417:421	APTST	SPOP	0.8174	More...
O94993	Transcription factor SOX-30	DEG_SPOP_SBC_1	725:729	APTST	SPOP	0.9793	More...
P16220	Cyclic AMP-responsive element-binding protein 1	DEG_SPOP_SBC_1	243:247	APTST	SPOP	0.9982	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	294:298	APTST	SPOP	0.9108	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	118:122	APTST	SPOP	0.9799	More...
P56270	Myc-associated zinc finger protein	DEG_SPOP_SBC_1	166:170	APTST	SPOP	0.7258	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3763:3767	APTST	SPOP	0.9554	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	DEG_SPOP_SBC_1	1083:1087	APTST	SPOP	0.9967	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	51:55	APTST	SPOP	0.925	More...
Q70E73	Ras-associated and pleckstrin homology domains-containing protein 1	DEG_SPOP_SBC_1	787:791	APTST	SPOP	0.9144	More...
Q8IV63	Inactive serine/threonine-protein kinase VRK3	DEG_SPOP_SBC_1	184:188	APTST	SPOP	0.8522	More...
Q8IW00	V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]	DEG_SPOP_SBC_1	304:308	APTST	SPOP	0.9964	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	131:135	APTST	SPOP	0.7089	More...
Q8WUU4	Zinc finger protein 296	DEG_SPOP_SBC_1	312:316	APTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12979:12983	APTST	SPOP	0.9309	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	168:172	APTST	SPOP	0.9958	More...
Q9C000	NACHT, LRR and PYD domains-containing protein 1	DEG_SPOP_SBC_1	176:180	APTST	SPOP	0.8015	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	903:907	APTST	SPOP	0.9701	More...
Q9UL54	Serine/threonine-protein kinase TAO2	DEG_SPOP_SBC_1	446:450	APTST	SPOP	0.9351	More...
Q5SXM8	DNL-type zinc finger protein	DEG_SPOP_SBC_1	154:158	APTST	SPOP	0.6422	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	403:407	APTST	SPOP	0.9592	More...
A6NMZ2	Sentan	DEG_SPOP_SBC_1	24:28	APTST	SPOP	0.9862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTST

Degron related mutations and impact score

Drug responses associated with HIPK2 mutations

All proteins holding degron of APTST