DegronMD - Q9UL54(TAOK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S453P	TCGA-86-A4JF	LUAD	TCGA	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.G323C	TCGA-97-7941	LUAD	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation rewiring degron network	0.2222
p.E900D	TCGA-A5-A1OF	UCEC	TCGA	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.6758
p.P910L	TCGA-AD-6890	COAD	TCGA	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.0556
p.S365N	TCGA-AX-A1C5	UCEC	TCGA	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.1111
p.P602S	TCGA-B5-A11G	UCEC	TCGA	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.6752
p.P602S	DO43514	UCEC	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.6752
p.E907K	TCGA-B7-5816	STAD	TCGA	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1389
p.S362C	TCGA-CV-6961	HNSC	TCGA	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.1944
p.M312I	TCGA-CV-7413	HNSC	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation rewiring degron network	0.3056
p.I315F	TCGA-E2-A15L	BRCA	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation altering degron motif	0.6304
p.Q616H	TCGA-EK-A2R8	CESC	TCGA	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation rewiring degron network	0.1111
p.Q616H	DO51599	CESC	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation rewiring degron network	0.1111
p.E900Q	TCGA-EK-A2R8	CESC	TCGA	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.6744
p.P324S	TCGA-EO-A22U	UCEC	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation rewiring degron network	0.1944
p.E336D	TCGA-G4-6588	COAD	TCGA	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.0556
p.F317L	TCGA-IP-7968	STAD	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation altering degron motif	0.6981
p.P605L	TCGA-QC-A7B5	SARC	TCGA	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.7582
p.P605L	TCGA-YG-AA3N	SKCM	TCGA	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.7582
p.P605L	DO220239	SARC	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.7582
p.P605L	DO51298	SKCM	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.7582
p.G894D	DO651	BLCA	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.7198
p.L896F	DO7938	COAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.6981
p.G595C	DO8786	COAD	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation substituting flanking lysine	0.25
p.A892V	DO9756	COAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.3056
p.R614I	DO222884	COCA	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation rewiring degron network	0.1667
p.R888C	DO234181	ESAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1944
p.E897Q	DO234415	ESAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.6744
p.P597S	DO22295	LGG	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation rewiring degron network	0.1944
p.A889S	DO229025	LICA	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.2222
p.C603F	DO229027	LICA	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.7108
p.L887Q	DO229054	LICA	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1667
p.R893H	DO48593	LIHC	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.8244
p.R893H	SIDM00217	Colorectal Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.8244
p.R893H	SNU-1040	large intestine	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.8244
p.RG906RS	DO222727	MELA	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0
p.S889F	DO37831	SKCM	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.2222
p.R891Q	DO37433	SKCM	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.2778
p.R903W	DO47451	SKCM	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.25
p.G907S	DO38028	SKCM	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1389
p.Q900H	DO47849	STAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.7582
p.G606C	DO47957	STAD	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.76
p.R615W	DO229218	THCA	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation rewiring degron network	0.1389
p.L614M	DO229227	THCA	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation rewiring degron network	0.1667
p.R898Q	DO42432	UCEC	ICGC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.7329
p.E618K	DO43755	UCEC	ICGC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation rewiring degron network	0.0556
p.P442R	SIDM00371	Pancreatic Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.P442R	ACH-000652	Pancreatic Cancer	CCLE	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.P442R	SUIT-2	pancreas	COSMIC	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.S894I	SIDM01261	Breast Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.7341
p.S894I	SIDM00314	Breast Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.7341
p.S894I	ACH-000097	Breast Cancer	CCLE	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.7341
p.S894I	ACH-002208	Breast Cancer	CCLE	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.7341
p.S894I	YMB-1-E	breast	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.7341
p.V354M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation altering degron motif	0.7208
p.V354M	ACH-002256	Leukemia	CCLE	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation altering degron motif	0.7208
p.V354M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation altering degron motif	0.7208
p.G343E	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.25
p.G343E	ACH-000893	Lung Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.25
p.G343E	NCI-H1651	lung	COSMIC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.25
p.E906Q	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1667
p.E906Q	ACH-000893	Lung Cancer	CCLE	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1667
p.E906Q	NCI-H1651	lung	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1667
p.R457W	SIDM01218	Other Solid Cancers	GDSC	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.R457W	ACH-001530	Endometrial/Uterine Cancer	CCLE	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.R457W	JEG-3	placenta	COSMIC	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.L316V	SIDM00217	Colorectal Carcinoma	GDSC	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation altering degron motif	0.5654
p.L316V	ACH-000999	Colon/Colorectal Cancer	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation altering degron motif	0.5654
p.L316V	SNU-1040	large intestine	COSMIC	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation altering degron motif	0.5654
p.P441L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.P441L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	APTST	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.E905D	SIDM00667	Other Sarcomas	GDSC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1944
p.E905D	Hs633T	soft tissue	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1944
p.A342S	SIDM01318	Hepatocellular Carcinoma	GDSC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.2222
p.A342S	ACH-001318	Liver Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.2222
p.P355L	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation altering degron motif	0.7582
p.P355L	ACH-000066	Lung Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation altering degron motif	0.7582
p.Y309C	SIDM01617	Endometrial Carcinoma	GDSC	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation blocking phosphorylation signal	0.6667
p.Y309C	ACH-000994	Endometrial/Uterine Cancer	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation blocking phosphorylation signal	0.6667
p.R888H	SIDM01776	Plasma Cell Myeloma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1944
p.R888H	ACH-001162	Myeloma	CCLE	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1944
p.Q899E	SIDM01347	Ovarian Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.6744
p.Q899E	ACH-000701	Ovarian Cancer	CCLE	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation altering degron motif	0.6744
p.R341Q	ACH-000144	Gastric Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.1944
p.R341Q	ACH-002391	Head and Neck Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.1944
p.R341Q	UDSCC2	upper aerodigestive tract	COSMIC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.1944
p.R341Q	RERF-GC-1B	stomach	COSMIC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation rewiring degron network	0.1944
p.H352Y	ACH-001540	Liposarcoma	CCLE	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation altering degron motif	0.6118
p.R905H	SNU-175	large intestine	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1944
p.G907R	SK-MEL-2	skin	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1389
p.G907R	Becker	central nervous system	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.1389
p.S603G	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PSTPKRE	DEG_SCF_FBW7_2	602:608	Mutation altering degron motif	0.6993
p.L883M	SK-MEL-1	skin	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	893:900	Mutation rewiring degron network	0.0556
p.S313F	NCI-H1355	lung	COSMIC	KKILFQE	LIG_APCC_ABBAyCdc20_2	313:319	Mutation altering degron motif	0.7982
p.R344W	RL95-2	endometrium	COSMIC	TSLESSHSVPSM	DEG_COP1_1	346:357	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for TAOK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAOK2

UniProt ID: Q9UL54

Entrez ID: 9344

Protein name: Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAOK2 in