DegronMD

Uniprot ID: Q9UL54

Source protein: Serine/threonine-protein kinase TAO2

Source gene: TAOK2

Class: LIG_APCC_ABBAyCdc20_2

Location: 313:319

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7443

ASA_SCORE: 108.0286

COIL: 0.3659

CONS_SCORE: 0.3615

DSS_SCORE: 0.4479

HELIX: 0.6213

FCONS_SCORE: 1.0536

RIG_SCORE: 0.7896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G323C	TCGA-97-7941	LUAD	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.M312I	TCGA-CV-7413	HNSC	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I315F	TCGA-E2-A15L	BRCA	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.6304
p.P324S	TCGA-EO-A22U	UCEC	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.F317L	TCGA-IP-7968	STAD	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L316V	SIDM00217	Colorectal Carcinoma	GDSC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L316V	ACH-000999	Colon/Colorectal Cancer	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L316V	SNU-1040	large_intestine	COSMIC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.5654
p.Y309C	SIDM01617	Endometrial Carcinoma	GDSC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.6667
p.Y309C	ACH-000994	Endometrial/Uterine Cancer	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.6667
p.S313F	NCI-H1355	lung	COSMIC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2K8	Serine/threonine-protein kinase TAO3	LIG_APCC_ABBAyCdc20_2	309:315	KKILFQE	APC,CDC20,FZR1	0.698	More...
Q9UL54	Serine/threonine-protein kinase TAO2	LIG_APCC_ABBAyCdc20_2	313:319	KKILFQE	APC,CDC20,FZR1	0.7443	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons