DegronMD - Q9H2K8(TAOK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T745A	TCGA-19-4065	GBM	TCGA	LEVTPKNE	DEG_SCF_FBW7_2	742:749	Mutation altering degron motif	0.825
p.E595K	TCGA-55-A490	LUAD	TCGA	HKENL	DEG_APCC_KENBOX_2	585:589	Mutation rewiring degron network	0.1667
p.E595K	DO24596	LUAD	ICGC	HKENL	DEG_APCC_KENBOX_2	585:589	Mutation rewiring degron network	0.1667
p.S583P	TCGA-97-7938	LUAD	TCGA	HKENL	DEG_APCC_KENBOX_2	585:589	Mutation rewiring degron network	0.2778
p.S583P	DO24329	LUAD	ICGC	HKENL	DEG_APCC_KENBOX_2	585:589	Mutation rewiring degron network	0.2778
p.R581W	TCGA-AA-A02R	COAD	TCGA	HKENL	DEG_APCC_KENBOX_2	585:589	Mutation rewiring degron network	0.2222
p.G319R	TCGA-BF-AAP2	SKCM	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.2222
p.G319R	TCGA-W3-AA1O	SKCM	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.2222
p.G319R	DO51274	SKCM	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.2222
p.G319R	DO219466	SKCM	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.2222
p.H591Y	TCGA-D5-6927	COAD	TCGA	HKENL	DEG_APCC_KENBOX_2	585:589	Mutation rewiring degron network	0.2778
p.H591Y	DO10332	COAD	ICGC	HKENL	DEG_APCC_KENBOX_2	585:589	Mutation rewiring degron network	0.2778
p.A736V	TCGA-MK-A84Z	THCA	TCGA	LEVTPKNE	DEG_SCF_FBW7_2	742:749	Mutation rewiring degron network	0.1667
p.E300K	DO225334	BRCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0833
p.R303T	DO49964	CESC	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.1667
p.E318Q	DO49964	CESC	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.25
p.M320V	DO222884	COCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.1944
p.A306D	DO228976	LICA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.25
p.Q579K	DO229015	LICA	ICGC	HKENL	DEG_APCC_KENBOX_2	585:589	Mutation rewiring degron network	0.1667
p.A321D	DO229028	LICA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.1667
p.Q311K	DO229025	LICA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6944
p.Q323K	DO229031	LICA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.1111
p.A324V	DO36531	READ	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation blocking phosphorylation signal	0.5278
p.L308S	DO51795	STAD	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.3056
p.R317Q	DO229268	THCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.2778
p.R317Q	ACH-000170	Non-Cancerous	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.2778
p.N318K	DO229240	THCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.25
p.F313L	DO229245	THCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6981
p.A306T	DO42280	UCEC	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.25
p.K310E	SIDM00217	Colorectal Carcinoma	GDSC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.591
p.K310E	ACH-000999	Colon/Colorectal Cancer	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.591
p.K310E	SNU-1040	large intestine	COSMIC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.591
p.Y305C	SIDM01617	Endometrial Carcinoma	GDSC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation blocking phosphorylation signal	0.6667
p.Y305C	ACH-000994	Endometrial/Uterine Cancer	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation blocking phosphorylation signal	0.6667
p.R303K	COR-L32	lung	COSMIC	KKILFQE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.1667

Kaplan plot for TAOK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAOK3

UniProt ID: Q9H2K8

Entrez ID: 51347

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAOK3 in