DegronMD

Uniprot ID: Q9H2K8

Source protein: Serine/threonine-protein kinase TAO3

Source gene: TAOK3

Class: DEG_APCC_KENBOX_2

Location: 585:589

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8655

ASA_SCORE: 107.46

COIL: 0.124

CONS_SCORE: 0.4295

DSS_SCORE: 0.6315

HELIX: 0.878

FCONS_SCORE: 1.067

RIG_SCORE: 0.6431

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E595K	TCGA-55-A490	LUAD	TCGA	HKENL	DEG_APCC_KENBOX_2	0.1667
p.E595K	DO24596	LUAD	ICGC	HKENL	DEG_APCC_KENBOX_2	0.1667
p.S583P	TCGA-97-7938	LUAD	TCGA	HKENL	DEG_APCC_KENBOX_2	0.2778
p.S583P	DO24329	LUAD	ICGC	HKENL	DEG_APCC_KENBOX_2	0.2778
p.R581W	TCGA-AA-A02R	COAD	TCGA	HKENL	DEG_APCC_KENBOX_2	0.2222
p.H591Y	TCGA-D5-6927	COAD	TCGA	HKENL	DEG_APCC_KENBOX_2	0.2778
p.H591Y	DO10332	COAD	ICGC	HKENL	DEG_APCC_KENBOX_2	0.2778
p.Q579K	DO229015	LICA	ICGC	HKENL	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2Y1	Myosin-7B	DEG_APCC_KENBOX_2	700:704	HKENL	APC,CDC20,FZR1	0.9422	More...
Q9H2K8	Serine/threonine-protein kinase TAO3	DEG_APCC_KENBOX_2	585:589	HKENL	APC,CDC20,FZR1	0.8655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons