DegronMD - A7E2Y1(MYH7B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S692L	TCGA-AG-A002	READ	TCGA	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1111
p.S692L	TCGA-D3-A8GI	SKCM	TCGA	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1111
p.S692L	DO50284	SKCM	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1111
p.H700Y	TCGA-B5-A1MX	UCEC	TCGA	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation altering degron motif	0.6118
p.H700Y	DO41999	UCEC	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation altering degron motif	0.6118
p.L711M	TCGA-B5-A1MX	UCEC	TCGA	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1389
p.L711M	DO41999	UCEC	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1389
p.S697F	TCGA-DD-AACU	LIHC	TCGA	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.25
p.S697F	DO52213	LIHC	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.25
p.R712L	TCGA-EE-A183	SKCM	TCGA	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1111
p.R712L	DO37715	SKCM	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1111
p.A690T	TCGA-KB-A93H	STAD	TCGA	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.0556
p.A690T	DO51747	STAD	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.0556
p.T695M	DO222905	BTCA	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1944
p.R712W	DO233731	GACA	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.1111
p.E702K	DO233909	GACA	ICGC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation altering degron motif	0.7022
p.K706N	SIDM00084	Glioblastoma	GDSC	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.2778
p.K706N	ACH-000376	Brain Cancer	CCLE	HKENL	DEG_APCC_KENBOX_2	700:704	Mutation rewiring degron network	0.2778

Kaplan plot for MYH7B in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYH7B

UniProt ID: A7E2Y1

Entrez ID: 57644

Protein name: Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MYH7B in