DegronMD

Uniprot ID: A7E2Y1

Source protein: Myosin-7B

Source gene: MYH7B

Class: DEG_APCC_KENBOX_2

Location: 700:704

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9422

ASA_SCORE: 54.32

COIL: 0.0952

CONS_SCORE: 0.8046

DSS_SCORE: 0.4154

HELIX: 0.8926

FCONS_SCORE: 1.1949

RIG_SCORE: 0.7867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S692L	TCGA-AG-A002	READ	TCGA	HKENL	DEG_APCC_KENBOX_2	0.1111
p.S692L	TCGA-D3-A8GI	SKCM	TCGA	HKENL	DEG_APCC_KENBOX_2	0.1111
p.S692L	DO50284	SKCM	ICGC	HKENL	DEG_APCC_KENBOX_2	0.1111
p.H700Y	TCGA-B5-A1MX	UCEC	TCGA	HKENL	DEG_APCC_KENBOX_2	0.6118
p.H700Y	DO41999	UCEC	ICGC	HKENL	DEG_APCC_KENBOX_2	0.6118
p.L711M	TCGA-B5-A1MX	UCEC	TCGA	HKENL	DEG_APCC_KENBOX_2	0.1389
p.L711M	DO41999	UCEC	ICGC	HKENL	DEG_APCC_KENBOX_2	0.1389
p.S697F	TCGA-DD-AACU	LIHC	TCGA	HKENL	DEG_APCC_KENBOX_2	0.25
p.S697F	DO52213	LIHC	ICGC	HKENL	DEG_APCC_KENBOX_2	0.25
p.R712L	TCGA-EE-A183	SKCM	TCGA	HKENL	DEG_APCC_KENBOX_2	0.1111
p.R712L	DO37715	SKCM	ICGC	HKENL	DEG_APCC_KENBOX_2	0.1111
p.A690T	TCGA-KB-A93H	STAD	TCGA	HKENL	DEG_APCC_KENBOX_2	0.0556
p.A690T	DO51747	STAD	ICGC	HKENL	DEG_APCC_KENBOX_2	0.0556
p.T695M	DO222905	BTCA	ICGC	HKENL	DEG_APCC_KENBOX_2	0.1944
p.R712W	DO233731	GACA	ICGC	HKENL	DEG_APCC_KENBOX_2	0.1111
p.E702K	DO233909	GACA	ICGC	HKENL	DEG_APCC_KENBOX_2	0.7022
p.K706N	SIDM00084	Glioblastoma	GDSC	HKENL	DEG_APCC_KENBOX_2	0.2778
p.K706N	ACH-000376	Brain Cancer	CCLE	HKENL	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2Y1	Myosin-7B	DEG_APCC_KENBOX_2	700:704	HKENL	APC,CDC20,FZR1	0.9422	More...
Q9H2K8	Serine/threonine-protein kinase TAO3	DEG_APCC_KENBOX_2	585:589	HKENL	APC,CDC20,FZR1	0.8655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons