DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LEVTPKNE
Uniprot ID:
Q9H2K8
Source protein:
Serine/threonine-protein kinase TAO3
Source gene:
TAOK3
Class:
DEG_SCF_FBW7_2
Location:
742:749
E3 ligase:
FBXW7
DEGRON score:
0.9276
ASA_SCORE:
105.4125
COIL:
0.614
CONS_SCORE:
0.4373
DSS_SCORE:
0.4257
HELIX:
0.3785
FCONS_SCORE:
1.0827
RIG_SCORE:
0.7355
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T745A
TCGA-19-4065
GBM
TCGA
LEVTPKNE
DEG_SCF_FBW7_2
0.825
p.A736V
TCGA-MK-A84Z
THCA
TCGA
LEVTPKNE
DEG_SCF_FBW7_2
0.1667
Drug responses associated with TAOK3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LEVTPKNE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H2K8
Serine/threonine-protein kinase TAO3
DEG_SCF_FBW7_2
742:749
LEVTPKNE
FBXW7
0.9276
More...