DegronMD

Uniprot ID: Q9H2K8

Source protein: Serine/threonine-protein kinase TAO3

Source gene: TAOK3

Class: LIG_APCC_ABBAyCdc20_2

Location: 309:315

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.698

ASA_SCORE: 100.6429

COIL: 0.388

CONS_SCORE: 0.426

DSS_SCORE: 0.4037

HELIX: 0.5594

FCONS_SCORE: 1.0291

RIG_SCORE: 0.8188

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F313L	DO229245	THCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.6981
p.Q311K	DO229025	LICA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.6944
p.Y305C	SIDM01617	Endometrial Carcinoma	GDSC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.6667
p.Y305C	ACH-000994	Endometrial/Uterine Cancer	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.6667
p.K310E	SIDM00217	Colorectal Carcinoma	GDSC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.591
p.K310E	ACH-000999	Colon/Colorectal Cancer	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.591
p.K310E	SNU-1040	large_intestine	COSMIC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.591
p.A324V	DO36531	READ	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.5278
p.L308S	DO51795	STAD	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R317Q	DO229268	THCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R317Q	ACH-000170	Non-Cancerous	CCLE	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E318Q	DO49964	CESC	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.A306D	DO228976	LICA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.N318K	DO229240	THCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.A306T	DO42280	UCEC	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.G319R	TCGA-BF-AAP2	SKCM	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G319R	TCGA-W3-AA1O	SKCM	TCGA	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G319R	DO51274	SKCM	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G319R	DO219466	SKCM	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.M320V	DO222884	COCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R303T	DO49964	CESC	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A321D	DO229028	LICA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R303K	COR-L32	lung	COSMIC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q323K	DO229031	LICA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E300K	DO225334	BRCA	ICGC	KKILFQE	LIG_APCC_ABBAyCdc20_2	0.0833

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Drug responses associated with TAOK3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of KKILFQE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL54	Serine/threonine-protein kinase TAO2	LIG_APCC_ABBAyCdc20_2	313:319	KKILFQE	APC,CDC20,FZR1	0.7443	More...
Q9H2K8	Serine/threonine-protein kinase TAO3	LIG_APCC_ABBAyCdc20_2	309:315	KKILFQE	APC,CDC20,FZR1	0.698	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKILFQE

Degron related mutations and impact score

Drug responses associated with TAOK3 mutations

All proteins holding degron of KKILFQE