DegronMD

Uniprot ID: Q9UL54

Source protein: Serine/threonine-protein kinase TAO2

Source gene: TAOK2

Class: DEG_COP1_1

Location: 346:357

E3 ligase: COP1

DEGRON score: 0.9836

ASA_SCORE: 87.8

COIL: 0.869

CONS_SCORE: 0.3245

DSS_SCORE: 0.608

HELIX: 0.0786

FCONS_SCORE: 0.9899

RIG_SCORE: 0.6271

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S365N	TCGA-AX-A1C5	UCEC	TCGA	TSLESSHSVPSM	DEG_COP1_1	0.1111
p.S362C	TCGA-CV-6961	HNSC	TCGA	TSLESSHSVPSM	DEG_COP1_1	0.1944
p.E336D	TCGA-G4-6588	COAD	TCGA	TSLESSHSVPSM	DEG_COP1_1	0.0556
p.V354M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TSLESSHSVPSM	DEG_COP1_1	0.7208
p.V354M	ACH-002256	Leukemia	CCLE	TSLESSHSVPSM	DEG_COP1_1	0.7208
p.V354M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TSLESSHSVPSM	DEG_COP1_1	0.7208
p.G343E	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	TSLESSHSVPSM	DEG_COP1_1	0.25
p.G343E	ACH-000893	Lung Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	0.25
p.G343E	NCI-H1651	lung	COSMIC	TSLESSHSVPSM	DEG_COP1_1	0.25
p.A342S	SIDM01318	Hepatocellular Carcinoma	GDSC	TSLESSHSVPSM	DEG_COP1_1	0.2222
p.A342S	ACH-001318	Liver Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	0.2222
p.P355L	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	TSLESSHSVPSM	DEG_COP1_1	0.7582
p.P355L	ACH-000066	Lung Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	0.7582
p.R341Q	ACH-000144	Gastric Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	0.1944
p.R341Q	ACH-002391	Head and Neck Cancer	CCLE	TSLESSHSVPSM	DEG_COP1_1	0.1944
p.R341Q	UDSCC2	upper_aerodigestive_tract	COSMIC	TSLESSHSVPSM	DEG_COP1_1	0.1944
p.R341Q	RERF-GC-1B	stomach	COSMIC	TSLESSHSVPSM	DEG_COP1_1	0.1944
p.H352Y	ACH-001540	Liposarcoma	CCLE	TSLESSHSVPSM	DEG_COP1_1	0.6118
p.R344W	RL95-2	endometrium	COSMIC	TSLESSHSVPSM	DEG_COP1_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL54	Serine/threonine-protein kinase TAO2	DEG_COP1_1	346:357	TSLESSHSVPSM	COP1	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons