DegronMD

Uniprot ID: Q9UL54

Source protein: Serine/threonine-protein kinase TAO2

Source gene: TAOK2

Class: DEG_SCF_FBW7_2

Location: 893:900

E3 ligase: FBXW7

DEGRON score: 0.9849

ASA_SCORE: 78.05

COIL: 0.7855

CONS_SCORE: 0.2872

DSS_SCORE: 0.8124

HELIX: 0.1003

FCONS_SCORE: 1.2303

RIG_SCORE: 0.6796

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E900D	TCGA-A5-A1OF	UCEC	TCGA	PALTPVPE	DEG_SCF_FBW7_2	0.6758
p.P910L	TCGA-AD-6890	COAD	TCGA	PALTPVPE	DEG_SCF_FBW7_2	0.0556
p.E907K	TCGA-B7-5816	STAD	TCGA	PALTPVPE	DEG_SCF_FBW7_2	0.1389
p.E900Q	TCGA-EK-A2R8	CESC	TCGA	PALTPVPE	DEG_SCF_FBW7_2	0.6744
p.G894D	DO651	BLCA	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.7198
p.L896F	DO7938	COAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.6981
p.A892V	DO9756	COAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.3056
p.R888C	DO234181	ESAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.1944
p.E897Q	DO234415	ESAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.6744
p.A889S	DO229025	LICA	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.2222
p.L887Q	DO229054	LICA	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.1667
p.R893H	DO48593	LIHC	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.8244
p.R893H	SIDM00217	Colorectal Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	0.8244
p.R893H	SNU-1040	large_intestine	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	0.8244
p.RG906RS	DO222727	MELA	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0
p.S889F	DO37831	SKCM	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.2222
p.R891Q	DO37433	SKCM	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.2778
p.R903W	DO47451	SKCM	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.25
p.G907S	DO38028	SKCM	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.1389
p.Q900H	DO47849	STAD	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.7582
p.R898Q	DO42432	UCEC	ICGC	PALTPVPE	DEG_SCF_FBW7_2	0.7329
p.S894I	SIDM01261	Breast Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	0.7341
p.S894I	SIDM00314	Breast Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	0.7341
p.S894I	ACH-000097	Breast Cancer	CCLE	PALTPVPE	DEG_SCF_FBW7_2	0.7341
p.S894I	ACH-002208	Breast Cancer	CCLE	PALTPVPE	DEG_SCF_FBW7_2	0.7341
p.S894I	YMB-1-E	breast	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	0.7341
p.E906Q	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	0.1667
p.E906Q	ACH-000893	Lung Cancer	CCLE	PALTPVPE	DEG_SCF_FBW7_2	0.1667
p.E906Q	NCI-H1651	lung	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	0.1667
p.E905D	SIDM00667	Other Sarcomas	GDSC	PALTPVPE	DEG_SCF_FBW7_2	0.1944
p.E905D	Hs633T	soft_tissue	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	0.1944
p.R888H	SIDM01776	Plasma Cell Myeloma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	0.1944
p.R888H	ACH-001162	Myeloma	CCLE	PALTPVPE	DEG_SCF_FBW7_2	0.1944
p.Q899E	SIDM01347	Ovarian Carcinoma	GDSC	PALTPVPE	DEG_SCF_FBW7_2	0.6744
p.Q899E	ACH-000701	Ovarian Cancer	CCLE	PALTPVPE	DEG_SCF_FBW7_2	0.6744
p.R905H	SNU-175	large_intestine	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	0.1944
p.G907R	SK-MEL-2	skin	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	0.1389
p.G907R	Becker	central_nervous_system	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	0.1389
p.L883M	SK-MEL-1	skin	COSMIC	PALTPVPE	DEG_SCF_FBW7_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PALTPVPE

Degron related mutations and impact score

Drug responses associated with TAOK2 mutations

All proteins holding degron of PALTPVPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL54	Serine/threonine-protein kinase TAO2	DEG_SCF_FBW7_2	893:900	PALTPVPE	FBXW7	0.9849	More...