DegronMD

Uniprot ID: Q9UL54

Source protein: Serine/threonine-protein kinase TAO2

Source gene: TAOK2

Class: DEG_SCF_FBW7_2

Location: 602:608

E3 ligase: FBXW7

DEGRON score: 0.518

ASA_SCORE: 100.0286

COIL: 0.5459

CONS_SCORE: 0.3323

DSS_SCORE: 0.5129

HELIX: 0.4569

FCONS_SCORE: 1.1125

RIG_SCORE: 0.651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P602S	TCGA-B5-A11G	UCEC	TCGA	PSTPKRE	DEG_SCF_FBW7_2	0.6752
p.P602S	DO43514	UCEC	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.6752
p.Q616H	TCGA-EK-A2R8	CESC	TCGA	PSTPKRE	DEG_SCF_FBW7_2	0.1111
p.Q616H	DO51599	CESC	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.1111
p.P605L	TCGA-QC-A7B5	SARC	TCGA	PSTPKRE	DEG_SCF_FBW7_2	0.7582
p.P605L	TCGA-YG-AA3N	SKCM	TCGA	PSTPKRE	DEG_SCF_FBW7_2	0.7582
p.P605L	DO220239	SARC	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.7582
p.P605L	DO51298	SKCM	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.7582
p.G595C	DO8786	COAD	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.25
p.R614I	DO222884	COCA	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.1667
p.P597S	DO22295	LGG	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.1944
p.C603F	DO229027	LICA	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.7108
p.G606C	DO47957	STAD	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.76
p.R615W	DO229218	THCA	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.1389
p.L614M	DO229227	THCA	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.1667
p.E618K	DO43755	UCEC	ICGC	PSTPKRE	DEG_SCF_FBW7_2	0.0556
p.S603G	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPKRE	DEG_SCF_FBW7_2	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL54	Serine/threonine-protein kinase TAO2	DEG_SCF_FBW7_2	602:608	PSTPKRE	FBXW7	0.518	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons