DegronMD - P16220(CREB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D116G	TCGA-56-A62T	LUSC	TCGA	YRKILNDLS	DEG_APCC_DBOX_1	120:128	Mutation rewiring degron network	0.2222
p.Q112H	TCGA-AP-A059	UCEC	TCGA	YRKILNDLS	DEG_APCC_DBOX_1	120:128	Mutation rewiring degron network	0.1111
p.L128I	TCGA-EO-A3B0	UCEC	TCGA	YRKILNDLS	DEG_APCC_DBOX_1	120:128	Mutation altering degron motif	0.7174
p.L128I	TCGA-EY-A1GI	UCEC	TCGA	YRKILNDLS	DEG_APCC_DBOX_1	120:128	Mutation altering degron motif	0.7174
p.E152Q	TCGA-LP-A4AW	CESC	TCGA	TTVTVPTP	DEG_COP1_1	152:159	Mutation altering degron motif	0.6744
p.E152Q	DO44373	CESC	ICGC	TTVTVPTP	DEG_COP1_1	152:159	Mutation altering degron motif	0.6744
p.T155M	DO222576	COCA	ICGC	TTVTVPTP	DEG_COP1_1	152:159	Mutation altering degron motif	0.6312
p.R241H	DO222769	COCA	ICGC	APTST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2778
p.E153G	DO45159	LIRI	ICGC	TTVTVPTP	DEG_COP1_1	152:159	Mutation altering degron motif	0.7199
p.D234N	DO220879	MELA	ICGC	APTST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.S147L	DO232858	NACA	ICGC	TTVTVPTP	DEG_COP1_1	152:159	Mutation rewiring degron network	0.1944
p.I248V	DO50690	ORCA	ICGC	APTST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.L114I	DO219773	UCEC	ICGC	YRKILNDLS	DEG_APCC_DBOX_1	120:128	Mutation rewiring degron network	0.1667
p.L114I	DO41211	UCEC	ICGC	YRKILNDLS	DEG_APCC_DBOX_1	120:128	Mutation rewiring degron network	0.1667
p.S111L	SIDM00190	Melanoma	GDSC	YRKILNDLS	DEG_APCC_DBOX_1	120:128	Mutation rewiring degron network	0.0833
p.S111L	CP66-MEL	skin	COSMIC	YRKILNDLS	DEG_APCC_DBOX_1	120:128	Mutation rewiring degron network	0.0833
p.L234V	SIDM00835	Colorectal Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.L234V	SW1116	large intestine	COSMIC	APTST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.P157L	ACH-002272	Lymphoma	CCLE	TTVTVPTP	DEG_COP1_1	152:159	Mutation altering degron motif	0.7582
p.P157L	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	TTVTVPTP	DEG_COP1_1	152:159	Mutation altering degron motif	0.7582
p.P250T	BHY	upper aerodigestive tract	COSMIC	APTST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.25
p.S164N	JVM-3	haematopoietic and lymphoid tissue	COSMIC	TTVTVPTP	DEG_COP1_1	152:159	Mutation rewiring degron network	0.1944

Kaplan plot for CREB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CREB1

UniProt ID: P16220

Entrez ID: 1385

Protein name: Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CREB1 in