DegronMD

Uniprot ID: P16220

Source protein: Cyclic AMP-responsive element-binding protein 1

Source gene: CREB1

Class: DEG_COP1_1

Location: 152:159

E3 ligase: COP1

DEGRON score: 0.9957

ASA_SCORE: 79.4375

COIL: 0.9139

CONS_SCORE: 0.5881

DSS_SCORE: 0.4658

HELIX: 0.0151

FCONS_SCORE: 1.0943

RIG_SCORE: 0.8088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E152Q	TCGA-LP-A4AW	CESC	TCGA	TTVTVPTP	DEG_COP1_1	0.6744
p.E152Q	DO44373	CESC	ICGC	TTVTVPTP	DEG_COP1_1	0.6744
p.T155M	DO222576	COCA	ICGC	TTVTVPTP	DEG_COP1_1	0.6312
p.E153G	DO45159	LIRI	ICGC	TTVTVPTP	DEG_COP1_1	0.7199
p.S147L	DO232858	NACA	ICGC	TTVTVPTP	DEG_COP1_1	0.1944
p.P157L	ACH-002272	Lymphoma	CCLE	TTVTVPTP	DEG_COP1_1	0.7582
p.P157L	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	TTVTVPTP	DEG_COP1_1	0.7582
p.S164N	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	TTVTVPTP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16220	Cyclic AMP-responsive element-binding protein 1	DEG_COP1_1	152:159	TTVTVPTP	COP1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons