DegronMD

Uniprot ID: P16220

Source protein: Cyclic AMP-responsive element-binding protein 1

Source gene: CREB1

Class: DEG_APCC_DBOX_1

Location: 120:128

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9871

ASA_SCORE: 83.6111

COIL: 0.4881

CONS_SCORE: 0.7265

DSS_SCORE: 0.5073

HELIX: 0.4689

FCONS_SCORE: 1.0131

RIG_SCORE: 0.7078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D116G	TCGA-56-A62T	LUSC	TCGA	YRKILNDLS	DEG_APCC_DBOX_1	0.2222
p.Q112H	TCGA-AP-A059	UCEC	TCGA	YRKILNDLS	DEG_APCC_DBOX_1	0.1111
p.L128I	TCGA-EO-A3B0	UCEC	TCGA	YRKILNDLS	DEG_APCC_DBOX_1	0.7174
p.L128I	TCGA-EY-A1GI	UCEC	TCGA	YRKILNDLS	DEG_APCC_DBOX_1	0.7174
p.L114I	DO219773	UCEC	ICGC	YRKILNDLS	DEG_APCC_DBOX_1	0.1667
p.L114I	DO41211	UCEC	ICGC	YRKILNDLS	DEG_APCC_DBOX_1	0.1667
p.S111L	SIDM00190	Melanoma	GDSC	YRKILNDLS	DEG_APCC_DBOX_1	0.0833
p.S111L	CP66-MEL	skin	COSMIC	YRKILNDLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16220	Cyclic AMP-responsive element-binding protein 1	DEG_APCC_DBOX_1	120:128	YRKILNDLS	APC,CDC20,FZR1	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons