DegronMD - O94993(SOX30)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V294L	TCGA-44-7669	LUAD	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.5654
p.V294L	DO25262	LUAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.5654
p.E282K	TCGA-A8-A093	BRCA	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1389
p.E282K	DO4161	BRCA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1389
p.P279S	TCGA-AC-A23H	BRCA	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.0556
p.P279S	DO2401	BRCA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.0556
p.I284V	TCGA-B0-4818	KIRC	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1944
p.I284V	DO20141	KIRC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1944
p.T727A	TCGA-B5-A3FC	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	725:729	Mutation altering degron motif	0.7139
p.L291M	TCGA-BR-8372	STAD	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.5999
p.L291M	DO47873	STAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.5999
p.S731C	TCGA-D8-A1J8	BRCA	TCGA	APTST	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.2778
p.L719F	TCGA-DA-A1I1	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1667
p.P293A	TCGA-EO-A3B0	UCEC	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.7503
p.P293A	DO219773	UCEC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.7503
p.S281L	TCGA-ER-A19G	SKCM	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1111
p.S281L	DO47284	SKCM	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1111
p.S300F	TCGA-OD-A75X	SKCM	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.2222
p.S300F	DO48601	SKCM	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.2222
p.L286S	TCGA-XK-AAIW	PRAD	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.25
p.L286S	DO51407	PRAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.25
p.F305L	DO1269	BRCA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.0833
p.F305L	DO51199	LUAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.0833
p.F119S	DO8490	COAD	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.2778
p.L291P	DO230346	COCA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.6471
p.Q124K	DO229005	COCA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation altering degron motif	0.6944
p.Q124K	DO228947	LICA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation altering degron motif	0.6944
p.P113L	DO233885	GACA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.A132V	DO233944	GACA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.25
p.P284Q	DO20942	KIRP	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1944
p.H283Q	DO228948	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1667
p.P282T	DO228974	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1389
p.H283N	DO229025	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1667
p.H283N	DO229035	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1667
p.H283N	DO229008	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1667
p.T123K	DO229031	LICA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation altering degron motif	0.7306
p.T129A	DO50788	LICA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation altering degron motif	0.7139
p.A132T	DO50970	LICA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.25
p.P295L	DO231909	LINC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.6471
p.R138L	DO51199	LUAD	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation substituting flanking lysine	0.1944
p.P280R	DO231033	LUSC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.0833
p.P280L	DO26444	LUSC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.0833
p.P280L	DO220851	MELA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.0833
p.T132I	DO227570	PACA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.25
p.I281M	DO37316	READ	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1111
p.P280S	DO48601	SKCM	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.0833
p.T297I	DO51761	STAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.3056
p.P289A	DO51737	STAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.7503
p.L292I	DO47869	STAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.7174
p.R138H	DO47785	STAD	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation substituting flanking lysine	0.1944
p.R138H	DO42280	UCEC	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation substituting flanking lysine	0.1944
p.R138H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation substituting flanking lysine	0.1944
p.G300R	DO42033	UCEC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.2222
p.R304I	DO41903	UCEC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1111
p.Q124H	DO41379	UCEC	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	121:129	Mutation altering degron motif	0.7582
p.T718A	SIDM00845	Burkitt's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.1389
p.P726L	SIDM00945	Colorectal Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	725:729	Mutation altering degron motif	0.6471
p.P726L	ACH-000895	Colon/Colorectal Cancer	CCLE	APTST	DEG_SPOP_SBC_1	725:729	Mutation altering degron motif	0.6471
p.P726L	CL-34	large intestine	COSMIC	APTST	DEG_SPOP_SBC_1	725:729	Mutation altering degron motif	0.6471
p.V722I	SIDM00537	Colorectal Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.25
p.V722I	ACH-001345	Colon/Colorectal Cancer	CCLE	APTST	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.25
p.V722I	GP5d	large intestine	COSMIC	APTST	DEG_SPOP_SBC_1	725:729	Mutation rewiring degron network	0.25
p.L301P	SIDM00901	Endometrial Carcinoma	GDSC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1944
p.L301P	ACH-000940	Endometrial/Uterine Cancer	CCLE	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1944
p.L301P	AN3-CA	endometrium	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1944
p.P304T	ACH-001433	Sarcoma	CCLE	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1111
p.P290T	OVTOKO	ovary	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.5919
p.P290T	OMC-1	cervix	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation altering degron motif	0.5919
p.T301R	NCI-H460	lung	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1944
p.P303L	NCI-H1876	lung	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	289:296	Mutation rewiring degron network	0.1389

Kaplan plot for SOX30 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX30

UniProt ID: O94993

Entrez ID: 11063

Protein name: Transcription factor SOX-30

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOX30 in