DegronMD

Uniprot ID: O94993

Source protein: Transcription factor SOX-30

Source gene: SOX30

Class: DEG_APCC_DBOX_1

Location: 121:129

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9715

ASA_SCORE: 86.6444

COIL: 0.8377

CONS_SCORE: 0.4349

DSS_SCORE: 0.6169

HELIX: 0.0976

FCONS_SCORE: 1.2715

RIG_SCORE: 0.6629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F119S	DO8490	COAD	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.2778
p.Q124K	DO229005	COCA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.6944
p.Q124K	DO228947	LICA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.6944
p.P113L	DO233885	GACA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.1111
p.A132V	DO233944	GACA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.25
p.T123K	DO229031	LICA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.7306
p.T129A	DO50788	LICA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.7139
p.A132T	DO50970	LICA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.25
p.R138L	DO51199	LUAD	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.1944
p.T132I	DO227570	PACA	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.25
p.R138H	DO47785	STAD	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.1944
p.R138H	DO42280	UCEC	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.1944
p.R138H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	SRPELHPVQ	DEG_APCC_DBOX_1	0.1944
p.Q124H	DO41379	UCEC	ICGC	SRPELHPVQ	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94993	Transcription factor SOX-30	DEG_APCC_DBOX_1	121:129	SRPELHPVQ	APC,CDC20,FZR1	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons