DegronMD

Uniprot ID: O94993

Source protein: Transcription factor SOX-30

Source gene: SOX30

Class: DEG_SCF_FBW7_1

Location: 289:296

E3 ligase: FBXW7

DEGRON score: 0.9647

ASA_SCORE: 91.3375

COIL: 0.9428

CONS_SCORE: 0.4822

DSS_SCORE: 0.3719

HELIX: 0.036

FCONS_SCORE: 0.9448

RIG_SCORE: 0.7601

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V294L	TCGA-44-7669	LUAD	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.5654
p.V294L	DO25262	LUAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.5654
p.E282K	TCGA-A8-A093	BRCA	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.1389
p.E282K	DO4161	BRCA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1389
p.P279S	TCGA-AC-A23H	BRCA	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.0556
p.P279S	DO2401	BRCA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.0556
p.I284V	TCGA-B0-4818	KIRC	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.1944
p.I284V	DO20141	KIRC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1944
p.L291M	TCGA-BR-8372	STAD	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.5999
p.L291M	DO47873	STAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.5999
p.P293A	TCGA-EO-A3B0	UCEC	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.7503
p.P293A	DO219773	UCEC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.7503
p.S281L	TCGA-ER-A19G	SKCM	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.1111
p.S281L	DO47284	SKCM	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1111
p.S300F	TCGA-OD-A75X	SKCM	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.2222
p.S300F	DO48601	SKCM	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.2222
p.L286S	TCGA-XK-AAIW	PRAD	TCGA	VPLTPVPT	DEG_SCF_FBW7_1	0.25
p.L286S	DO51407	PRAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.25
p.F305L	DO1269	BRCA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.0833
p.F305L	DO51199	LUAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.0833
p.L291P	DO230346	COCA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.6471
p.P284Q	DO20942	KIRP	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1944
p.H283Q	DO228948	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1667
p.P282T	DO228974	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1389
p.H283N	DO229025	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1667
p.H283N	DO229035	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1667
p.H283N	DO229008	LICA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1667
p.P295L	DO231909	LINC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.6471
p.P280R	DO231033	LUSC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.0833
p.P280L	DO26444	LUSC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.0833
p.P280L	DO220851	MELA	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.0833
p.I281M	DO37316	READ	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1111
p.P280S	DO48601	SKCM	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.0833
p.T297I	DO51761	STAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.3056
p.P289A	DO51737	STAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.7503
p.L292I	DO47869	STAD	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.7174
p.G300R	DO42033	UCEC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.2222
p.R304I	DO41903	UCEC	ICGC	VPLTPVPT	DEG_SCF_FBW7_1	0.1111
p.L301P	SIDM00901	Endometrial Carcinoma	GDSC	VPLTPVPT	DEG_SCF_FBW7_1	0.1944
p.L301P	ACH-000940	Endometrial/Uterine Cancer	CCLE	VPLTPVPT	DEG_SCF_FBW7_1	0.1944
p.L301P	AN3-CA	endometrium	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	0.1944
p.P304T	ACH-001433	Sarcoma	CCLE	VPLTPVPT	DEG_SCF_FBW7_1	0.1111
p.P290T	OVTOKO	ovary	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	0.5919
p.P290T	OMC-1	cervix	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	0.5919
p.T301R	NCI-H460	lung	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	0.1944
p.P303L	NCI-H1876	lung	COSMIC	VPLTPVPT	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPLTPVPT

Degron related mutations and impact score

Drug responses associated with SOX30 mutations

All proteins holding degron of VPLTPVPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94993	Transcription factor SOX-30	DEG_SCF_FBW7_1	289:296	VPLTPVPT	FBXW7	0.9647	More...