DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
APTST
Uniprot ID:
Q8IW00
Source protein:
V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]
Source gene:
VSTM4
Class:
DEG_SPOP_SBC_1
Location:
304:308
E3 ligase:
SPOP
DEGRON score:
0.9964
ASA_SCORE:
70.88
COIL:
0.8304
CONS_SCORE:
0.6535
DSS_SCORE:
0.2669
HELIX:
0.0166
FCONS_SCORE:
0.8385
RIG_SCORE:
0.7218
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E317K
TCGA-D3-A2J8
SKCM
TCGA
APTST
DEG_SPOP_SBC_1
0.0833
p.E317K
TCGA-FS-A4F5
SKCM
TCGA
APTST
DEG_SPOP_SBC_1
0.0833
p.E317K
DO227496
LAML
ICGC
APTST
DEG_SPOP_SBC_1
0.0833
p.E317K
DO231101
LAML
ICGC
APTST
DEG_SPOP_SBC_1
0.0833
p.E317K
DO37881
SKCM
ICGC
APTST
DEG_SPOP_SBC_1
0.0833
p.E317K
DO37778
SKCM
ICGC
APTST
DEG_SPOP_SBC_1
0.0833
p.L314I
TCGA-F1-6874
STAD
TCGA
APTST
DEG_SPOP_SBC_1
0.1667
p.L314I
DO38201
STAD
ICGC
APTST
DEG_SPOP_SBC_1
0.1667
p.P305H
TCGA-FS-A1ZY
SKCM
TCGA
APTST
DEG_SPOP_SBC_1
0.6583
p.P305H
DO38135
SKCM
ICGC
APTST
DEG_SPOP_SBC_1
0.6583
p.E316K
TCGA-HQ-A2OE
BLCA
TCGA
APTST
DEG_SPOP_SBC_1
0.1111
p.E316K
DO540
BLCA
ICGC
APTST
DEG_SPOP_SBC_1
0.1111
p.A304T
TCGA-ZG-A9LZ
PRAD
TCGA
APTST
DEG_SPOP_SBC_1
0.7139
p.A304T
DO227820
BRCA
ICGC
APTST
DEG_SPOP_SBC_1
0.7139
p.A304T
DO219440
PRAD
ICGC
APTST
DEG_SPOP_SBC_1
0.7139
p.H298L
DO232026
LICA
ICGC
APTST
DEG_SPOP_SBC_1
0.1667
p.T308A
ACH-001991
Primary
CCLE
APTST
DEG_SPOP_SBC_1
0.7139
Drug responses associated with VSTM4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of APTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15068
Guanine nucleotide exchange factor DBS
DEG_SPOP_SBC_1
970:974
APTST
SPOP
0.8568
More...
O15446
DNA-directed RNA polymerase I subunit RPA34
DEG_SPOP_SBC_1
417:421
APTST
SPOP
0.8174
More...
O94993
Transcription factor SOX-30
DEG_SPOP_SBC_1
725:729
APTST
SPOP
0.9793
More...
P16220
Cyclic AMP-responsive element-binding protein 1
DEG_SPOP_SBC_1
243:247
APTST
SPOP
0.9982
More...
P51532
Transcription activator BRG1
DEG_SPOP_SBC_1
294:298
APTST
SPOP
0.9108
More...
P54727
UV excision repair protein RAD23 homolog B
DEG_SPOP_SBC_1
118:122
APTST
SPOP
0.9799
More...
P56270
Myc-associated zinc finger protein
DEG_SPOP_SBC_1
166:170
APTST
SPOP
0.7258
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3763:3767
APTST
SPOP
0.9554
More...
Q15303
Receptor tyrosine-protein kinase erbB-4
DEG_SPOP_SBC_1
1083:1087
APTST
SPOP
0.9967
More...
Q5VT06
Centrosome-associated protein 350
DEG_SPOP_SBC_1
51:55
APTST
SPOP
0.925
More...
Q70E73
Ras-associated and pleckstrin homology domains-containing protein 1
DEG_SPOP_SBC_1
787:791
APTST
SPOP
0.9144
More...
Q8IV63
Inactive serine/threonine-protein kinase VRK3
DEG_SPOP_SBC_1
184:188
APTST
SPOP
0.8522
More...
Q8IW00
V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]
DEG_SPOP_SBC_1
304:308
APTST
SPOP
0.9964
More...
Q8NEZ2
Vacuolar protein sorting-associated protein 37A
DEG_SPOP_SBC_1
131:135
APTST
SPOP
0.7089
More...
Q8WUU4
Zinc finger protein 296
DEG_SPOP_SBC_1
312:316
APTST
SPOP
0.9874
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
12979:12983
APTST
SPOP
0.9309
More...
Q96F05
Uncharacterized protein C11orf24
DEG_SPOP_SBC_1
168:172
APTST
SPOP
0.9958
More...
Q9C000
NACHT, LRR and PYD domains-containing protein 1
DEG_SPOP_SBC_1
176:180
APTST
SPOP
0.8015
More...
Q9H2X6
Homeodomain-interacting protein kinase 2
DEG_SPOP_SBC_1
903:907
APTST
SPOP
0.9701
More...
Q9UL54
Serine/threonine-protein kinase TAO2
DEG_SPOP_SBC_1
446:450
APTST
SPOP
0.9351
More...
Q5SXM8
DNL-type zinc finger protein
DEG_SPOP_SBC_1
154:158
APTST
SPOP
0.6422
More...
Q9H0E3
Histone deacetylase complex subunit SAP130
DEG_SPOP_SBC_1
403:407
APTST
SPOP
0.9592
More...
A6NMZ2
Sentan
DEG_SPOP_SBC_1
24:28
APTST
SPOP
0.9862
More...