DegronMD - Q8IV63(VRK3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P109L	TCGA-A5-A0G2	UCEC	TCGA	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.3056
p.Q110H	TCGA-AC-A5XS	BRCA	TCGA	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.2778
p.G178D	TCGA-AJ-A23O	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.S95F	TCGA-DX-A8BP	SARC	TCGA	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation blocking phosphorylation signal	0.5833
p.S95F	DO220056	SARC	ICGC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation blocking phosphorylation signal	0.5833
p.R94Q	DO230326	COCA	ICGC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.1111
p.S77R	DO222813	COCA	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S77R	DO222813	COCA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.S77R	JHOS-4	ovary	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S77R	JHOS-4	ovary	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.S77R	T-T	oesophagus	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S77R	T-T	oesophagus	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.S77R	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S77R	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.S77R	SNU-407	large intestine	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S77R	SNU-407	large intestine	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.S77R	TK	haematopoietic and lymphoid tissue	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S77R	TK	haematopoietic and lymphoid tissue	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.S77R	HSC-39	stomach	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S77R	HSC-39	stomach	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.S77R	SAT	upper aerodigestive tract	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S77R	SAT	upper aerodigestive tract	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.C78G	DO222813	COCA	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.76
p.C78G	DO222813	COCA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.76
p.C78G	DO46424	OV	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.76
p.C78G	DO46424	OV	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.76
p.L118P	DO234407	ESAD	ICGC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.0556
p.R73Q	DO233261	GACA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7329
p.R92Q	DO233272	GACA	ICGC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.0556
p.R92Q	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.0556
p.C78S	DO228218	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7541
p.C78S	DO228218	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7541
p.C78S	DO46424	OV	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7541
p.C78S	DO46424	OV	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7541
p.M195L	DO228617	LICA	ICGC	APTST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.T89K	DO228952	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0556
p.T89K	DO228952	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.0556
p.T89K	DO229022	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0556
p.T89K	DO229022	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.0556
p.S79R	DO229019	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7427
p.S79R	DO229019	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7427
p.T69N	DO229019	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1944
p.T69N	DO229019	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.2222
p.S65R	DO229026	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0833
p.S65R	DO229026	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.1111
p.A190D	DO229038	LICA	ICGC	APTST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2778
p.G196S	DO50970	LICA	ICGC	APTST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.R94L	DO26522	LUSC	ICGC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.1111
p.S185L	DO222843	MELA	ICGC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7667
p.E100K	DO29208	OV	ICGC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.2778
p.T109I	DO35460	PACA	ICGC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.3056
p.S72G	DO43274	UCEC	ICGC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.2778
p.S72G	DO43274	UCEC	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.3056
p.R114Q	DO41638	UCEC	ICGC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation substituting flanking lysine	0.2778
p.T188A	SIDM00773	Non-Cancerous	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00845	Burkitt's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01090	Colorectal Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00454	Rhabdomyosarcoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01117	Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00210	Ovarian Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01112	Osteosarcoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00849	Kidney Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00875	Breast Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00863	Burkitt's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00721	Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00774	Breast Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01140	Ovarian Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00257	Neuroblastoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00760	Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01173	Rhabdomyosarcoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM00628	Breast Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01318	Hepatocellular Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01409	Bladder Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.T188A	SIDM01752	Pancreatic Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.P105T	SIDM00773	Non-Cancerous	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00845	Burkitt's Lymphoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01090	Colorectal Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00454	Rhabdomyosarcoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00210	Ovarian Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01112	Osteosarcoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00849	Kidney Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00875	Breast Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00863	Burkitt's Lymphoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00774	Breast Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01140	Ovarian Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00257	Neuroblastoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00760	Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01173	Rhabdomyosarcoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM00628	Breast Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01318	Hepatocellular Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01409	Bladder Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.P105T	SIDM01752	Pancreatic Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation altering degron motif	0.7031
p.G80S	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.3056
p.G80S	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.3056
p.G80S	SIDM00850	Gastric Carcinoma	GDSC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.3056
p.G80S	SIDM00850	Gastric Carcinoma	GDSC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.3056
p.G80S	ACH-000496	Lung Cancer	CCLE	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.3056
p.G80S	ACH-000496	Lung Cancer	CCLE	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.3056
p.G80S	ACH-000880	Gastric Cancer	CCLE	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.3056
p.G80S	ACH-000880	Gastric Cancer	CCLE	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.3056
p.G80S	AGS	stomach	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.3056
p.G80S	AGS	stomach	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.3056
p.G80S	NCI-H1792	lung	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.3056
p.G80S	NCI-H1792	lung	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.3056
p.V69I	SIDM01608	Endometrial Carcinoma	GDSC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1944
p.V69I	SIDM01608	Endometrial Carcinoma	GDSC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.2222
p.V69I	ACH-000990	Endometrial/Uterine Cancer	CCLE	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1944
p.V69I	ACH-000990	Endometrial/Uterine Cancer	CCLE	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.2222
p.G178R	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.G99R	ACH-000501	Colon/Colorectal Cancer	CCLE	PPTPKSS	DEG_SCF_FBW7_1	102:108	Mutation rewiring degron network	0.25
p.E84V	ACH-001814	Bone Cancer	CCLE	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1944
p.E84V	ACH-001814	Bone Cancer	CCLE	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation rewiring degron network	0.1944
p.C78Y	JHOS-4	ovary	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7087
p.C78Y	JHOS-4	ovary	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7087
p.C78Y	ABC-1	lung	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7087
p.C78Y	ABC-1	lung	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7087
p.N178S	EN	endometrium	COSMIC	APTST	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.K75M	TE-11	oesophagus	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.8062
p.K75M	TE-11	oesophagus	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.8062
p.C78R	JHOS-4	ovary	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.8301
p.C78R	JHOS-4	ovary	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.8301
p.C78W	JHOS-4	ovary	COSMIC	LSLFSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7
p.C78W	JHOS-4	ovary	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	73:79	Mutation altering degron motif	0.7

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VRK3

UniProt ID: Q8IV63

Entrez ID: 51231

Protein name: Inactive serine/threonine-protein kinase VRK3 (Serine/threonine-protein pseudokinase VRK3) (Vaccinia-related kinase 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VRK3 in