DegronMD

Uniprot ID: Q8IV63

Source protein: Inactive serine/threonine-protein kinase VRK3

Source gene: VRK3

Class: DEG_SCF_FBW7_1

Location: 102:108

E3 ligase: FBXW7

DEGRON score: 0.9821

ASA_SCORE: 98.8857

COIL: 0.9643

CONS_SCORE: 0.3184

DSS_SCORE: 0.8754

HELIX: 0.0114

FCONS_SCORE: 1.0621

RIG_SCORE: 0.467

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P109L	TCGA-A5-A0G2	UCEC	TCGA	PPTPKSS	DEG_SCF_FBW7_1	0.3056
p.Q110H	TCGA-AC-A5XS	BRCA	TCGA	PPTPKSS	DEG_SCF_FBW7_1	0.2778
p.S95F	TCGA-DX-A8BP	SARC	TCGA	PPTPKSS	DEG_SCF_FBW7_1	0.5833
p.S95F	DO220056	SARC	ICGC	PPTPKSS	DEG_SCF_FBW7_1	0.5833
p.R94Q	DO230326	COCA	ICGC	PPTPKSS	DEG_SCF_FBW7_1	0.1111
p.L118P	DO234407	ESAD	ICGC	PPTPKSS	DEG_SCF_FBW7_1	0.0556
p.R92Q	DO233272	GACA	ICGC	PPTPKSS	DEG_SCF_FBW7_1	0.0556
p.R92Q	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPKSS	DEG_SCF_FBW7_1	0.0556
p.R94L	DO26522	LUSC	ICGC	PPTPKSS	DEG_SCF_FBW7_1	0.1111
p.E100K	DO29208	OV	ICGC	PPTPKSS	DEG_SCF_FBW7_1	0.2778
p.T109I	DO35460	PACA	ICGC	PPTPKSS	DEG_SCF_FBW7_1	0.3056
p.R114Q	DO41638	UCEC	ICGC	PPTPKSS	DEG_SCF_FBW7_1	0.2778
p.P105T	SIDM00773	Non-Cancerous	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00845	Burkitt's Lymphoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01090	Colorectal Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00454	Rhabdomyosarcoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00210	Ovarian Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01112	Osteosarcoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00849	Kidney Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00875	Breast Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00863	Burkitt's Lymphoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00774	Breast Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01140	Ovarian Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00257	Neuroblastoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00760	Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01173	Rhabdomyosarcoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM00628	Breast Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01318	Hepatocellular Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01409	Bladder Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.P105T	SIDM01752	Pancreatic Carcinoma	GDSC	PPTPKSS	DEG_SCF_FBW7_1	0.7031
p.G99R	ACH-000501	Colon/Colorectal Cancer	CCLE	PPTPKSS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPKSS

Degron related mutations and impact score

Drug responses associated with VRK3 mutations

All proteins holding degron of PPTPKSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV63	Inactive serine/threonine-protein kinase VRK3	DEG_SCF_FBW7_1	102:108	PPTPKSS	FBXW7	0.9821	More...