DegronMD

Uniprot ID: Q8IV63

Source protein: Inactive serine/threonine-protein kinase VRK3

Source gene: VRK3

Class: LIG_APCC_ABBA_1

Location: 74:79

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9996

ASA_SCORE: 79.4167

COIL: 0.8345

CONS_SCORE: 0.4295

DSS_SCORE: 0.5251

HELIX: 0.1118

FCONS_SCORE: 1.0923

RIG_SCORE: 0.6877

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S77R	DO222813	COCA	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.S77R	JHOS-4	ovary	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.S77R	T-T	oesophagus	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.S77R	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.S77R	SNU-407	large_intestine	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.S77R	TK	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.S77R	HSC-39	stomach	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.S77R	SAT	upper_aerodigestive_tract	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.C78G	DO222813	COCA	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.76
p.C78G	DO46424	OV	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.76
p.C78S	DO228218	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.7541
p.C78S	DO46424	OV	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.7541
p.T89K	DO228952	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.0556
p.T89K	DO229022	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.0556
p.S79R	DO229019	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.7427
p.T69N	DO229019	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.1944
p.S65R	DO229026	LICA	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.0833
p.S72G	DO43274	UCEC	ICGC	LSLFSD	LIG_APCC_ABBA_1	0.2778
p.G80S	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	LSLFSD	LIG_APCC_ABBA_1	0.3056
p.G80S	SIDM00850	Gastric Carcinoma	GDSC	LSLFSD	LIG_APCC_ABBA_1	0.3056
p.G80S	ACH-000496	Lung Cancer	CCLE	LSLFSD	LIG_APCC_ABBA_1	0.3056
p.G80S	ACH-000880	Gastric Cancer	CCLE	LSLFSD	LIG_APCC_ABBA_1	0.3056
p.G80S	AGS	stomach	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.3056
p.G80S	NCI-H1792	lung	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.3056
p.V69I	SIDM01608	Endometrial Carcinoma	GDSC	LSLFSD	LIG_APCC_ABBA_1	0.1944
p.V69I	ACH-000990	Endometrial/Uterine Cancer	CCLE	LSLFSD	LIG_APCC_ABBA_1	0.1944
p.E84V	ACH-001814	Bone Cancer	CCLE	LSLFSD	LIG_APCC_ABBA_1	0.1944
p.C78Y	JHOS-4	ovary	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7087
p.C78Y	ABC-1	lung	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7087
p.K75M	TE-11	oesophagus	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.8062
p.C78R	JHOS-4	ovary	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.8301
p.C78W	JHOS-4	ovary	COSMIC	LSLFSD	LIG_APCC_ABBA_1	0.7

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSLFSD

Degron related mutations and impact score

Drug responses associated with VRK3 mutations

All proteins holding degron of LSLFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV63	Inactive serine/threonine-protein kinase VRK3	LIG_APCC_ABBA_1	74:79	LSLFSD	APC,CDC20,FZR1	0.9996	More...