DegronMD

Uniprot ID: Q8IV63

Source protein: Inactive serine/threonine-protein kinase VRK3

Source gene: VRK3

Class: LIG_APCC_ABBAyCdc20_2

Location: 73:79

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9782

ASA_SCORE: 88.7286

COIL: 0.8497

CONS_SCORE: 0.4219

DSS_SCORE: 0.5107

HELIX: 0.0994

FCONS_SCORE: 1.0826

RIG_SCORE: 0.6941

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S77R	DO222813	COCA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.S77R	JHOS-4	ovary	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.S77R	T-T	oesophagus	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.S77R	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.S77R	SNU-407	large_intestine	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.S77R	TK	haematopoietic_and_lymphoid_tissue	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.S77R	HSC-39	stomach	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.S77R	SAT	upper_aerodigestive_tract	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.C78G	DO222813	COCA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.76
p.C78G	DO46424	OV	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.76
p.R73Q	DO233261	GACA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7329
p.C78S	DO228218	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7541
p.C78S	DO46424	OV	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7541
p.T89K	DO228952	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.T89K	DO229022	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S79R	DO229019	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7427
p.T69N	DO229019	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S65R	DO229026	LICA	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S72G	DO43274	UCEC	ICGC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G80S	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G80S	SIDM00850	Gastric Carcinoma	GDSC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G80S	ACH-000496	Lung Cancer	CCLE	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G80S	ACH-000880	Gastric Cancer	CCLE	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G80S	AGS	stomach	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G80S	NCI-H1792	lung	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V69I	SIDM01608	Endometrial Carcinoma	GDSC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V69I	ACH-000990	Endometrial/Uterine Cancer	CCLE	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84V	ACH-001814	Bone Cancer	CCLE	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.C78Y	JHOS-4	ovary	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7087
p.C78Y	ABC-1	lung	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7087
p.K75M	TE-11	oesophagus	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.8062
p.C78R	JHOS-4	ovary	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.8301
p.C78W	JHOS-4	ovary	COSMIC	RLSLFSD	LIG_APCC_ABBAyCdc20_2	0.7

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RLSLFSD

Degron related mutations and impact score

Drug responses associated with VRK3 mutations

All proteins holding degron of RLSLFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV63	Inactive serine/threonine-protein kinase VRK3	LIG_APCC_ABBAyCdc20_2	73:79	RLSLFSD	APC,CDC20,FZR1	0.9782	More...