DegronMD

Uniprot ID: Q8IV63

Source protein: Inactive serine/threonine-protein kinase VRK3

Source gene: VRK3

Class: DEG_SPOP_SBC_1

Location: 184:188

E3 ligase: SPOP

DEGRON score: 0.8522

ASA_SCORE: 50.12

COIL: 0.5944

CONS_SCORE: 0.3026

DSS_SCORE: 0.4334

HELIX: 0.0646

FCONS_SCORE: 0.7866

RIG_SCORE: 0.75

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G178D	TCGA-AJ-A23O	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	0.1667
p.M195L	DO228617	LICA	ICGC	APTST	DEG_SPOP_SBC_1	0.1389
p.A190D	DO229038	LICA	ICGC	APTST	DEG_SPOP_SBC_1	0.2778
p.G196S	DO50970	LICA	ICGC	APTST	DEG_SPOP_SBC_1	0.1111
p.S185L	DO222843	MELA	ICGC	APTST	DEG_SPOP_SBC_1	0.7667
p.T188A	SIDM00773	Non-Cancerous	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00845	Burkitt's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01090	Colorectal Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00454	Rhabdomyosarcoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01117	Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00210	Ovarian Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01112	Osteosarcoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00849	Kidney Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00875	Breast Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00863	Burkitt's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00721	Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00774	Breast Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01140	Ovarian Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00257	Neuroblastoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00760	Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01173	Rhabdomyosarcoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM00628	Breast Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01318	Hepatocellular Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01409	Bladder Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.T188A	SIDM01752	Pancreatic Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	0.7139
p.G178R	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	0.1667
p.N178S	EN	endometrium	COSMIC	APTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15068	Guanine nucleotide exchange factor DBS	DEG_SPOP_SBC_1	970:974	APTST	SPOP	0.8568	More...
O15446	DNA-directed RNA polymerase I subunit RPA34	DEG_SPOP_SBC_1	417:421	APTST	SPOP	0.8174	More...
O94993	Transcription factor SOX-30	DEG_SPOP_SBC_1	725:729	APTST	SPOP	0.9793	More...
P16220	Cyclic AMP-responsive element-binding protein 1	DEG_SPOP_SBC_1	243:247	APTST	SPOP	0.9982	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	294:298	APTST	SPOP	0.9108	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	118:122	APTST	SPOP	0.9799	More...
P56270	Myc-associated zinc finger protein	DEG_SPOP_SBC_1	166:170	APTST	SPOP	0.7258	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3763:3767	APTST	SPOP	0.9554	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	DEG_SPOP_SBC_1	1083:1087	APTST	SPOP	0.9967	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	51:55	APTST	SPOP	0.925	More...
Q70E73	Ras-associated and pleckstrin homology domains-containing protein 1	DEG_SPOP_SBC_1	787:791	APTST	SPOP	0.9144	More...
Q8IV63	Inactive serine/threonine-protein kinase VRK3	DEG_SPOP_SBC_1	184:188	APTST	SPOP	0.8522	More...
Q8IW00	V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]	DEG_SPOP_SBC_1	304:308	APTST	SPOP	0.9964	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	131:135	APTST	SPOP	0.7089	More...
Q8WUU4	Zinc finger protein 296	DEG_SPOP_SBC_1	312:316	APTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12979:12983	APTST	SPOP	0.9309	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	168:172	APTST	SPOP	0.9958	More...
Q9C000	NACHT, LRR and PYD domains-containing protein 1	DEG_SPOP_SBC_1	176:180	APTST	SPOP	0.8015	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	903:907	APTST	SPOP	0.9701	More...
Q9UL54	Serine/threonine-protein kinase TAO2	DEG_SPOP_SBC_1	446:450	APTST	SPOP	0.9351	More...
Q5SXM8	DNL-type zinc finger protein	DEG_SPOP_SBC_1	154:158	APTST	SPOP	0.6422	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	403:407	APTST	SPOP	0.9592	More...
A6NMZ2	Sentan	DEG_SPOP_SBC_1	24:28	APTST	SPOP	0.9862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTST

Degron related mutations and impact score

Drug responses associated with VRK3 mutations

All proteins holding degron of APTST