DegronMD - Q8WUU4(ZNF296)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L317V	TCGA-85-A4CL	LUSC	TCGA	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.3056
p.L317V	DO45454	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.3056
p.G437C	TCGA-AR-A1AT	BRCA	TCGA	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.3056
p.G437C	DO1275	BRCA	ICGC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.3056
p.R433C	TCGA-BR-4257	STAD	TCGA	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.1944
p.R433C	DO38683	STAD	ICGC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.1944
p.P306L	TCGA-CD-A4MI	STAD	TCGA	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1667
p.P306L	DO47717	STAD	ICGC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1667
p.P306L	ACH-001566	Skin Cancer	CCLE	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1667
p.K428R	TCGA-D3-A3MR	SKCM	TCGA	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation substituting flanking lysine	0.1667
p.K428R	DO47256	SKCM	ICGC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation substituting flanking lysine	0.1667
p.R431H	TCGA-D7-A4YT	STAD	TCGA	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.1389
p.R431H	DO47723	STAD	ICGC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.1389
p.P304L	TCGA-D7-A4YU	STAD	TCGA	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1111
p.P304L	DO47761	STAD	ICGC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1111
p.P304L	SIDM00201	Ewing's Sarcoma	GDSC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1111
p.P304L	EW-7	bone	COSMIC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1111
p.E305Q	TCGA-L5-A4OT	ESCA	TCGA	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1389
p.G326E	DO228540	LICA	ICGC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0556
p.H432N	DO229018	LICA	ICGC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.1667
p.A311D	DO229041	LICA	ICGC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.3056
p.A310V	SIDM01149	Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.A310V	ACH-001365	Lung Cancer	CCLE	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.A310V	NCI-H847	lung	COSMIC	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.R444H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.3056
p.R444H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.3056
p.R434H	SIDM00217	Colorectal Carcinoma	GDSC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.2222
p.R434H	ACH-000999	Colon/Colorectal Cancer	CCLE	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.2222
p.R434H	SNU-1040	large intestine	COSMIC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.2222
p.P306S	ACH-001566	Skin Cancer	CCLE	APTST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1667
p.D437Y	GR-ST	haematopoietic and lymphoid tissue	COSMIC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.3056
p.T435A	GP5d	large intestine	COSMIC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.25
p.E450K	ZR-75-30	breast	COSMIC	MTPGST	DEG_SCF_FBW7_1	438:443	Mutation rewiring degron network	0.1389

Kaplan plot for ZNF296 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF296

UniProt ID: Q8WUU4

Entrez ID: 162979

Protein name: Zinc finger protein 296 (ZFP296) (Zinc finger protein 342)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF296 in