DegronMD

Uniprot ID: Q8WUU4

Source protein: Zinc finger protein 296

Source gene: ZNF296

Class: DEG_SCF_FBW7_1

Location: 438:443

E3 ligase: FBXW7

DEGRON score: 0.9634

ASA_SCORE: 77.55

COIL: 0.9118

CONS_SCORE: 0.5118

DSS_SCORE: 0.3653

HELIX: 0.0223

FCONS_SCORE: 0.6983

RIG_SCORE: 0.6153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G437C	TCGA-AR-A1AT	BRCA	TCGA	MTPGST	DEG_SCF_FBW7_1	0.3056
p.G437C	DO1275	BRCA	ICGC	MTPGST	DEG_SCF_FBW7_1	0.3056
p.R433C	TCGA-BR-4257	STAD	TCGA	MTPGST	DEG_SCF_FBW7_1	0.1944
p.R433C	DO38683	STAD	ICGC	MTPGST	DEG_SCF_FBW7_1	0.1944
p.K428R	TCGA-D3-A3MR	SKCM	TCGA	MTPGST	DEG_SCF_FBW7_1	0.1667
p.K428R	DO47256	SKCM	ICGC	MTPGST	DEG_SCF_FBW7_1	0.1667
p.R431H	TCGA-D7-A4YT	STAD	TCGA	MTPGST	DEG_SCF_FBW7_1	0.1389
p.R431H	DO47723	STAD	ICGC	MTPGST	DEG_SCF_FBW7_1	0.1389
p.H432N	DO229018	LICA	ICGC	MTPGST	DEG_SCF_FBW7_1	0.1667
p.R444H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	MTPGST	DEG_SCF_FBW7_1	0.3056
p.R444H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	MTPGST	DEG_SCF_FBW7_1	0.3056
p.R434H	SIDM00217	Colorectal Carcinoma	GDSC	MTPGST	DEG_SCF_FBW7_1	0.2222
p.R434H	ACH-000999	Colon/Colorectal Cancer	CCLE	MTPGST	DEG_SCF_FBW7_1	0.2222
p.R434H	SNU-1040	large_intestine	COSMIC	MTPGST	DEG_SCF_FBW7_1	0.2222
p.D437Y	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	MTPGST	DEG_SCF_FBW7_1	0.3056
p.T435A	GP5d	large_intestine	COSMIC	MTPGST	DEG_SCF_FBW7_1	0.25
p.E450K	ZR-75-30	breast	COSMIC	MTPGST	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUU4	Zinc finger protein 296	DEG_SCF_FBW7_1	438:443	MTPGST	FBXW7	0.9634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons