DegronMD - O15068(MCF2L)

FUNCTION: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250|UniProtKB:Q63406, ECO:0000269|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269|PubMed:15157669}.

GO - Biological processes (BP): intracellular signal transduction [GO:0035556]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056]

GO - Molecular function (MF): guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol binding [GO:0035091]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R47L	DO224612	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.8428
p.R49H	TCGA-BR-6452	STAD	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.8244
p.R47H	DO38404	STAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.8244
p.G973R	DO220056	SARC	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7568
p.V975I	DO230342	COCA	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation blocking phosphorylation signal	0.75
p.V975I	DO42568	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation blocking phosphorylation signal	0.75
p.T45M	DO10132	COAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7423
p.A970T	DO222492	COCA	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7139
p.Y970C	TCGA-A5-A0G2	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7087
p.V971I	TCGA-A5-A1OF	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7076
p.V971I	SIDM00101	Mesothelioma	GDSC	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7076
p.V971I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7076
p.D45N	L-428	haematopoietic and lymphoid tissue	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6932
p.P49S	TCGA-3N-A9WD	SKCM	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6752
p.P49S	DO51235	SKCM	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6752
p.A51S	ACH-001518	Endometrial/Uterine Cancer	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6477
p.L965I	TCGA-A4-7583	KIRP	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation blocking phosphorylation signal	0.6389
p.Q46K	TCGA-KQ-A41N	BLCA	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5833
p.Q46K	DO223588	BLCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5833
p.A51V	SIDM02059	Colorectal Carcinoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5825

Showing 1 to 20 of 74 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCF2L

UniProt ID: O15068

Entrez ID: 23263

Protein name: Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCF2L in