DegronMD - O15068(MCF2L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E50Q	TCGA-34-7107	LUSC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5633
p.E50Q	DO26449	LUSC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5633
p.P49S	TCGA-3N-A9WD	SKCM	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6752
p.P49S	DO51235	SKCM	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6752
p.L965I	TCGA-A4-7583	KIRP	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation blocking phosphorylation signal	0.6389
p.R57W	TCGA-A5-A0G2	UCEC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.R57W	TCGA-B5-A3FC	UCEC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.R57W	TCGA-CV-7101	HNSC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.R57W	SIDM01608	Endometrial Carcinoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.R57W	ACH-000990	Endometrial/Uterine Cancer	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.Y970C	TCGA-A5-A0G2	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7087
p.V971I	TCGA-A5-A1OF	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7076
p.V971I	SIDM00101	Mesothelioma	GDSC	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7076
p.V971I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7076
p.R57Q	TCGA-A6-6781	COAD	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.R57Q	TCGA-FB-AAQ0	PAAD	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.K984R	TCGA-AA-3672	COAD	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.0556
p.A60T	TCGA-AP-A1DK	UCEC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1111
p.A60T	DO42033	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1111
p.S39P	TCGA-AP-A1DV	UCEC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1667
p.S39P	DO43186	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1667
p.Q35K	TCGA-BF-A1Q0	SKCM	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0556
p.Q35K	DO47374	SKCM	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0556
p.R49H	TCGA-BR-6452	STAD	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.8244
p.T977A	TCGA-CG-5733	STAD	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.25
p.G969R	TCGA-DX-A8BP	SARC	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.3056
p.P980L	TCGA-ER-A42K	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1667
p.Q46K	TCGA-KQ-A41N	BLCA	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5833
p.Q46K	DO223588	BLCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5833
p.E962K	DO49976	CESC	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1111
p.T45M	DO10132	COAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7423
p.R55Q	DO8447	COAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.25
p.R55Q	DO51685	PAAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.25
p.V975I	DO230342	COCA	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation blocking phosphorylation signal	0.75
p.V975I	DO42568	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation blocking phosphorylation signal	0.75
p.T36M	DO227802	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.A55T	DO227987	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.25
p.R47L	DO224612	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.8428
p.A970T	DO222492	COCA	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7139
p.G59S	DO222874	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1389
p.R61W	DO15310	HNSC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.R61W	DO41871	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.R61W	DO41235	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.L969I	DO20870	KIRP	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.3056
p.A44S	DO228978	LICA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.3056
p.M54I	DO229031	LICA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2778
p.V41F	DO229041	LICA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2222
p.P967T	DO22866	LIHC	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.25
p.R62C	DO220909	MELA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0556
p.N983S	DO32616	OV	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.0833
p.G973R	DO220056	SARC	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7568
p.P976A	DO219468	SKCM	ICGC	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.2778
p.R47H	DO38404	STAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.8244
p.A53V	DO229221	THCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.3056
p.S39T	DO42977	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1667
p.T41M	DO43907	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2222
p.A51V	SIDM02059	Colorectal Carcinoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5825
p.A51V	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5825
p.A51V	ACH-000964	Leukemia	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5825
p.D41N	SIDM00327	Hodgkin's Lymphoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2222
p.D41N	ACH-000754	Lymphoma	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2222
p.D41N	L-428	haematopoietic and lymphoid tissue	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2222
p.R43S	SIDM00864	Cervical Carcinoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2778
p.R43S	ACH-001341	Cervical Cancer	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2778
p.R43S	DoTc2-4510	cervix	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.2778
p.A51S	ACH-001518	Endometrial/Uterine Cancer	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6477
p.L961V	HeLa	cervix	COSMIC	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.0833
p.D39N	L-428	haematopoietic and lymphoid tissue	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1667
p.D45N	L-428	haematopoietic and lymphoid tissue	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6932
p.L966Q	L-1236	haematopoietic and lymphoid tissue	COSMIC	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.2222
p.A59T	LN-229	central nervous system	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1389
p.G60D	NCI-H810	lung	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1111
p.I38F	HMV-II	skin	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1389
p.L969Q	L-1236	haematopoietic and lymphoid tissue	COSMIC	APTST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCF2L

UniProt ID: O15068

Entrez ID: 23263

Protein name: Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCF2L in