DegronMD

Uniprot ID: O15068

Source protein: Guanine nucleotide exchange factor DBS

Source gene: MCF2L

Class: DEG_SCF_FBW7_1

Location: 45:52

E3 ligase: FBXW7

DEGRON score: 0.6879

ASA_SCORE: 78.5625

COIL: 0.5963

CONS_SCORE: 0.1032

DSS_SCORE: 0.4452

HELIX: 0.3805

FCONS_SCORE: 0.667

RIG_SCORE: 0.7751

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E50Q	TCGA-34-7107	LUSC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.5633
p.E50Q	DO26449	LUSC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.5633
p.P49S	TCGA-3N-A9WD	SKCM	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.6752
p.P49S	DO51235	SKCM	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.6752
p.R57W	TCGA-A5-A0G2	UCEC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.1944
p.R57W	TCGA-B5-A3FC	UCEC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.1944
p.R57W	TCGA-CV-7101	HNSC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.1944
p.R57W	SIDM01608	Endometrial Carcinoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	0.1944
p.R57W	ACH-000990	Endometrial/Uterine Cancer	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	0.1944
p.R57Q	TCGA-A6-6781	COAD	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.1944
p.R57Q	TCGA-FB-AAQ0	PAAD	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.1944
p.A60T	TCGA-AP-A1DK	UCEC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.1111
p.A60T	DO42033	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.1111
p.S39P	TCGA-AP-A1DV	UCEC	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.1667
p.S39P	DO43186	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.1667
p.Q35K	TCGA-BF-A1Q0	SKCM	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.0556
p.Q35K	DO47374	SKCM	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.0556
p.R49H	TCGA-BR-6452	STAD	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.8244
p.Q46K	TCGA-KQ-A41N	BLCA	TCGA	VQDTPEAT	DEG_SCF_FBW7_1	0.5833
p.Q46K	DO223588	BLCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.5833
p.T45M	DO10132	COAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.7423
p.R55Q	DO8447	COAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.25
p.R55Q	DO51685	PAAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.25
p.T36M	DO227802	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.0833
p.A55T	DO227987	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.25
p.R47L	DO224612	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.8428
p.G59S	DO222874	COCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.1389
p.R61W	DO15310	HNSC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.0833
p.R61W	DO41871	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.0833
p.R61W	DO41235	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.0833
p.A44S	DO228978	LICA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.3056
p.M54I	DO229031	LICA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.2778
p.V41F	DO229041	LICA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.2222
p.R62C	DO220909	MELA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.0556
p.R47H	DO38404	STAD	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.8244
p.A53V	DO229221	THCA	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.3056
p.S39T	DO42977	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.1667
p.T41M	DO43907	UCEC	ICGC	VQDTPEAT	DEG_SCF_FBW7_1	0.2222
p.A51V	SIDM02059	Colorectal Carcinoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	0.5825
p.A51V	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	0.5825
p.A51V	ACH-000964	Leukemia	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	0.5825
p.D41N	SIDM00327	Hodgkin's Lymphoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	0.2222
p.D41N	ACH-000754	Lymphoma	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	0.2222
p.D41N	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	0.2222
p.R43S	SIDM00864	Cervical Carcinoma	GDSC	VQDTPEAT	DEG_SCF_FBW7_1	0.2778
p.R43S	ACH-001341	Cervical Cancer	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	0.2778
p.R43S	DoTc2-4510	cervix	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	0.2778
p.A51S	ACH-001518	Endometrial/Uterine Cancer	CCLE	VQDTPEAT	DEG_SCF_FBW7_1	0.6477
p.D39N	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	0.1667
p.D45N	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	0.6932
p.A59T	LN-229	central_nervous_system	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	0.1389
p.G60D	NCI-H810	lung	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	0.1111
p.I38F	HMV-II	skin	COSMIC	VQDTPEAT	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQDTPEAT

Degron related mutations and impact score

Drug responses associated with MCF2L mutations

All proteins holding degron of VQDTPEAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15068	Guanine nucleotide exchange factor DBS	DEG_SCF_FBW7_1	45:52	VQDTPEAT	FBXW7	0.6879	More...