DegronMD - Q70E73(RAPH1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V567I	TCGA-2W-A8YY	CESC	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1667
p.V567I	SIDM00392	Melanoma	GDSC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1667
p.V567I	ACH-000810	Skin Cancer	CCLE	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1667
p.V567I	SK-MEL-30	skin	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1667
p.K959N	TCGA-61-1727	OV	TCGA	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation substituting flanking lysine	0.2778
p.P919A	TCGA-77-8140	LUSC	TCGA	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.1944
p.P910T	TCGA-A5-A0GB	UCEC	TCGA	SSIPVPSP	DEG_COP1_1	907:914	Mutation altering degron motif	0.5919
p.S571I	TCGA-AP-A051	UCEC	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation blocking phosphorylation signal	0.5
p.R568C	TCGA-BH-A1EN	BRCA	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1389
p.V567A	TCGA-F7-A624	HNSC	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1667
p.H566L	TCGA-NC-A5HJ	LUSC	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1944
p.V914M	DO8786	COAD	ICGC	SSIPVPSP	DEG_COP1_1	907:914	Mutation altering degron motif	0.7208
p.P909L	DO9658	COAD	ICGC	SSIPVPSP	DEG_COP1_1	907:914	Mutation altering degron motif	0.7582
p.P906S	DO234209	ESAD	ICGC	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.3056
p.A568D	DO228976	LICA	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1389
p.A568D	DO229022	LICA	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1389
p.N564K	DO229034	LICA	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.25
p.Q560K	DO229045	LICA	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation altering degron motif	0.6944
p.K915N	DO218937	LUAD	ICGC	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.3056
p.P787Q	DO26959	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	787:791	Mutation altering degron motif	0.7035
p.R553H	DO46657	PAAD	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.2778
p.F898C	DO230497	PRAD	ICGC	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.0833
p.P795L	DO46808	PRAD	ICGC	APTST	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.2222
p.V913I	DO41871	UCEC	ICGC	SSIPVPSP	DEG_COP1_1	907:914	Mutation altering degron motif	0.7076
p.S919I	DO42568	UCEC	ICGC	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.1944
p.P962T	DO41434	UCEC	ICGC	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation substituting flanking lysine	0.1944
p.T963M	SIDM00845	Burkitt's Lymphoma	GDSC	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation rewiring degron network	0.0556
p.T963M	SIDM01519	Head and Neck Carcinoma	GDSC	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation rewiring degron network	0.0556
p.T963M	ACH-000786	Lymphoma	CCLE	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation rewiring degron network	0.0556
p.T963M	ACH-000992	Head and Neck Cancer	CCLE	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation rewiring degron network	0.0556
p.T963M	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation rewiring degron network	0.0556
p.S953G	SIDM00845	Burkitt's Lymphoma	GDSC	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation altering degron motif	0.6993
p.S953G	ACH-000786	Lymphoma	CCLE	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation altering degron motif	0.6993
p.P778L	SIDM00516	Melanoma	GDSC	APTST	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.0833
p.P778L	ACH-002166	Skin Cancer	CCLE	APTST	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.0833
p.P778L	MZ7-mel	skin	COSMIC	APTST	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.0833
p.Q905H	SIDM00217	Colorectal Carcinoma	GDSC	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.2778
p.Q905H	ACH-000999	Colon/Colorectal Cancer	CCLE	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.2778
p.Q905H	SNU-1040	large intestine	COSMIC	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.2778
p.G557A	SIDM00289	B-Lymphoblastic Leukemia	GDSC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation altering degron motif	0.754
p.G557A	ACH-002241	Leukemia	CCLE	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation altering degron motif	0.754
p.G557A	HAL-01	haematopoietic and lymphoid tissue	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation altering degron motif	0.754
p.V798E	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.1389
p.V911A	SIDM01451	Pancreatic Carcinoma	GDSC	SSIPVPSP	DEG_COP1_1	907:914	Mutation altering degron motif	0.6936
p.V911A	ACH-000635	Ovarian Cancer	CCLE	SSIPVPSP	DEG_COP1_1	907:914	Mutation altering degron motif	0.6936
p.V911A	ACH-000933	Pancreatic Cancer	CCLE	SSIPVPSP	DEG_COP1_1	907:914	Mutation altering degron motif	0.6936
p.G557V	ACH-001143	Lymphoma	CCLE	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation altering degron motif	0.7532
p.P956S	ACH-001694	Head and Neck Cancer	CCLE	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation rewiring degron network	0.25
p.P942L	ACH-002039	Pancreatic Cancer	CCLE	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation rewiring degron network	0.1667
p.P924R	H4	central nervous system	COSMIC	SSIPVPSP	DEG_COP1_1	907:914	Mutation rewiring degron network	0.0556
p.L782P	CML-T1	haematopoietic and lymphoid tissue	COSMIC	APTST	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.1944
p.L782P	8505C	thyroid	COSMIC	APTST	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.1944
p.Y557C	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation altering degron motif	0.7087
p.S567N	HEC-1	endometrium	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation rewiring degron network	0.1667
p.Q957H	SNU-1040	large intestine	COSMIC	PTPDKS	DEG_SCF_FBW7_1	948:953	Mutation rewiring degron network	0.2222
p.A794V	GR-ST	haematopoietic and lymphoid tissue	COSMIC	APTST	DEG_SPOP_SBC_1	787:791	Mutation rewiring degron network	0.25
p.S569N	HEC-1	endometrium	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	555:561	Mutation blocking phosphorylation signal	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAPH1

UniProt ID: Q70E73

Entrez ID: 65059

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAPH1 in