DegronMD

Uniprot ID: Q70E73

Source protein: Ras-associated and pleckstrin homology domains-containing protein 1

Source gene: RAPH1

Class: DEG_COP1_1

Location: 907:914

E3 ligase: COP1

DEGRON score: 0.9565

ASA_SCORE: 89.2875

COIL: 0.97

CONS_SCORE: 0.3304

DSS_SCORE: 0.6147

HELIX: 0.0143

FCONS_SCORE: 0.7647

RIG_SCORE: 0.544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P919A	TCGA-77-8140	LUSC	TCGA	SSIPVPSP	DEG_COP1_1	0.1944
p.P910T	TCGA-A5-A0GB	UCEC	TCGA	SSIPVPSP	DEG_COP1_1	0.5919
p.V914M	DO8786	COAD	ICGC	SSIPVPSP	DEG_COP1_1	0.7208
p.P909L	DO9658	COAD	ICGC	SSIPVPSP	DEG_COP1_1	0.7582
p.P906S	DO234209	ESAD	ICGC	SSIPVPSP	DEG_COP1_1	0.3056
p.K915N	DO218937	LUAD	ICGC	SSIPVPSP	DEG_COP1_1	0.3056
p.F898C	DO230497	PRAD	ICGC	SSIPVPSP	DEG_COP1_1	0.0833
p.V913I	DO41871	UCEC	ICGC	SSIPVPSP	DEG_COP1_1	0.7076
p.S919I	DO42568	UCEC	ICGC	SSIPVPSP	DEG_COP1_1	0.1944
p.Q905H	SIDM00217	Colorectal Carcinoma	GDSC	SSIPVPSP	DEG_COP1_1	0.2778
p.Q905H	ACH-000999	Colon/Colorectal Cancer	CCLE	SSIPVPSP	DEG_COP1_1	0.2778
p.Q905H	SNU-1040	large_intestine	COSMIC	SSIPVPSP	DEG_COP1_1	0.2778
p.V911A	SIDM01451	Pancreatic Carcinoma	GDSC	SSIPVPSP	DEG_COP1_1	0.6936
p.V911A	ACH-000635	Ovarian Cancer	CCLE	SSIPVPSP	DEG_COP1_1	0.6936
p.V911A	ACH-000933	Pancreatic Cancer	CCLE	SSIPVPSP	DEG_COP1_1	0.6936
p.P924R	H4	central_nervous_system	COSMIC	SSIPVPSP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70E73	Ras-associated and pleckstrin homology domains-containing protein 1	DEG_COP1_1	907:914	SSIPVPSP	COP1	0.9565	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons