DegronMD

Uniprot ID: Q70E73

Source protein: Ras-associated and pleckstrin homology domains-containing protein 1

Source gene: RAPH1

Class: DEG_SCF_TRCP1_1

Location: 555:561

E3 ligase: BTRC

DEGRON score: 0.959

ASA_SCORE: 81.8571

COIL: 0.927

CONS_SCORE: 0.3767

DSS_SCORE: 0.7336

HELIX: 0.0466

FCONS_SCORE: 0.8862

RIG_SCORE: 0.5667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V567I	TCGA-2W-A8YY	CESC	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	0.1667
p.V567I	SIDM00392	Melanoma	GDSC	DSGVSDT	DEG_SCF_TRCP1_1	0.1667
p.V567I	ACH-000810	Skin Cancer	CCLE	DSGVSDT	DEG_SCF_TRCP1_1	0.1667
p.V567I	SK-MEL-30	skin	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	0.1667
p.S571I	TCGA-AP-A051	UCEC	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	0.5
p.R568C	TCGA-BH-A1EN	BRCA	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	0.1389
p.V567A	TCGA-F7-A624	HNSC	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	0.1667
p.H566L	TCGA-NC-A5HJ	LUSC	TCGA	DSGVSDT	DEG_SCF_TRCP1_1	0.1944
p.A568D	DO228976	LICA	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	0.1389
p.A568D	DO229022	LICA	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	0.1389
p.N564K	DO229034	LICA	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	0.25
p.Q560K	DO229045	LICA	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	0.6944
p.R553H	DO46657	PAAD	ICGC	DSGVSDT	DEG_SCF_TRCP1_1	0.2778
p.G557A	SIDM00289	B-Lymphoblastic Leukemia	GDSC	DSGVSDT	DEG_SCF_TRCP1_1	0.754
p.G557A	ACH-002241	Leukemia	CCLE	DSGVSDT	DEG_SCF_TRCP1_1	0.754
p.G557A	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	0.754
p.G557V	ACH-001143	Lymphoma	CCLE	DSGVSDT	DEG_SCF_TRCP1_1	0.7532
p.Y557C	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	0.7087
p.S567N	HEC-1	endometrium	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	0.1667
p.S569N	HEC-1	endometrium	COSMIC	DSGVSDT	DEG_SCF_TRCP1_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70E73	Ras-associated and pleckstrin homology domains-containing protein 1	DEG_SCF_TRCP1_1	555:561	DSGVSDT	BTRC	0.959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons