DegronMD

Uniprot ID: Q70E73

Source protein: Ras-associated and pleckstrin homology domains-containing protein 1

Source gene: RAPH1

Class: DEG_SCF_FBW7_1

Location: 948:953

E3 ligase: FBXW7

DEGRON score: 0.9786

ASA_SCORE: 106.1167

COIL: 0.9607

CONS_SCORE: 0.2753

DSS_SCORE: 0.8292

HELIX: 0.0212

FCONS_SCORE: 0.7032

RIG_SCORE: 0.4521

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K959N	TCGA-61-1727	OV	TCGA	PTPDKS	DEG_SCF_FBW7_1	0.2778
p.P962T	DO41434	UCEC	ICGC	PTPDKS	DEG_SCF_FBW7_1	0.1944
p.T963M	SIDM00845	Burkitt's Lymphoma	GDSC	PTPDKS	DEG_SCF_FBW7_1	0.0556
p.T963M	SIDM01519	Head and Neck Carcinoma	GDSC	PTPDKS	DEG_SCF_FBW7_1	0.0556
p.T963M	ACH-000786	Lymphoma	CCLE	PTPDKS	DEG_SCF_FBW7_1	0.0556
p.T963M	ACH-000992	Head and Neck Cancer	CCLE	PTPDKS	DEG_SCF_FBW7_1	0.0556
p.T963M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PTPDKS	DEG_SCF_FBW7_1	0.0556
p.S953G	SIDM00845	Burkitt's Lymphoma	GDSC	PTPDKS	DEG_SCF_FBW7_1	0.6993
p.S953G	ACH-000786	Lymphoma	CCLE	PTPDKS	DEG_SCF_FBW7_1	0.6993
p.P956S	ACH-001694	Head and Neck Cancer	CCLE	PTPDKS	DEG_SCF_FBW7_1	0.25
p.P942L	ACH-002039	Pancreatic Cancer	CCLE	PTPDKS	DEG_SCF_FBW7_1	0.1667
p.Q957H	SNU-1040	large_intestine	COSMIC	PTPDKS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70E73	Ras-associated and pleckstrin homology domains-containing protein 1	DEG_SCF_FBW7_1	948:953	PTPDKS	FBXW7	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons